Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 03 / 08 / 2021

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REVIEW ARTICLE

2019 Chinese Clinical Practice Guidelines for the Prevention of Mother-to-child Transmission of Hepatitis B Virus

Caiyun NieJinfeng Liu#,1,2, Tianyan Chen#,1,2Yaolong Chen#,3,4Hong Ren*,5Guiqiang Wang*,6Wenhong Zhang*,7Yingren Zhao*,1,2 and Society of Infectious Diseases and Chinese Medical Association

1  The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
2  Shaanxi Clinical Research Center of Infectious Diseases, Xi’an, Shaanxi, China
3  Evidence-Based Medicine Center, Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China
4  WHO Collaborating Centre for Guideline Implementation and Knowledge Translation, Lanzhou, Gansu, China
5  Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
6  Hepatology Center, Department of Infectious Diseases, Peking University First Hospital, Beijing, China
7  Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai, China
#These authors contributed equally to this work.
*Correspondence to: Yingren Zhao, Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China. Tel: +86-13509187086, Fax: +86-29-85324594, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Hong Ren, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Guiqiang Wang, Hepatology Center, Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Wenhong Zhang, Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2020;8(4):397-406 DOI: 10.14218/JCTH.2020.00070
Received: July 22, 2020 Accepted: September 8, 2020 Published online: December 15, 2020

Abstract

To develop the evidence-based guidelines for managing mother-to-child transmission of hepatitis B virus in China, a multidisciplinary guideline development group was established. Clinical questions were identified from two rounds of surveys on the concerns of first-line clinicians. We conducted a comprehensive search and review of the literature. A grading of recommendations’ assessment, development, and evaluation system was adopted to rate the quality of evidence and the strength of recommendations. Recommendations were formulated based on the evidence, overall balance of benefits and harms (at individual and population levels), patient/health worker values and preferences, resources available, cost-effectiveness, and feasibility. Eventually, recommendations related to 13 main clinical concerns were developed, covering diagnostic criteria, treatment indications, antiviral therapy choice, timing to initiate and discontinue treatment, immunoprophylaxis strategy at birth, and how to deal with special situations, such as unintended pregnancy, assisted reproduction, and breastfeeding. The guidelines are intended to serve as guidance for clinicians and patients, to optimize the management of majority of pregnant women who are positive for hepatitis B surface antigen. Guideline registration: International Practice Guide Registration Platform (IPGRP-2018CN040).

Keywords

Hepatitis B virus, Mother-to-child transmission, Clinical practice guidelines, Prevention, GRADE

Journal of Clinical and Translational Hepatology 2020 vol. 8, 397-406 [ Html  ] [ PDF Full-text ]

© The Authors 2020. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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