Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Wednesday, 04 / 21 / 2021

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REVIEW ARTICLE

Noncanonical NF-κB Signaling Pathway in Liver Diseases

Qianhui Chen1, Xinyu Lu1 and Xiaoyong Zhang1,2

1  State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou,Guangdong, China
2  Hepatology Unit, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China
*Correspondence to: Xiaoyong Zhang, Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, Guangdong 510515, China. Tel: +86-20-62787830, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(1):51-59 DOI: 10.14218/JCTH.2020.00057
Received: July 13, 2020 Accepted: November 23, 2020 Published online: December 21, 2020

Abstract

The noncanonical NF-κB signaling pathway is an important branch of NF-κB signaling. It is involved in regulating multiple important biological processes, including inflammation and host immune response. A central adaptor protein of the noncanonical NF-κB pathway is NF-κB-inducing kinase (NIK), which activates the downstream kinase IKKα to process p100 to p52, thereby forming the RelB/p52 heterodimer to initiate the expression of target genes. Currently, many specific inhibitors and monoclonal antibodies targeting or triggering this pathway are being developed and tested for various diseases, including cancers, autoimmune diseases, and virus infection. Given that aberrant activation of the noncanonical NF-κB pathway is frequently observed in various liver diseases, targeting this pathway may be a promising therapeutic strategy to alleviate liver inflammation. Moreover, activation of this pathway may contribute to the antiviral immune response and promote the clearance of persistent hepatotropic virus infection. Here, we review the role of the noncanonical NF-κB pathway in the occurrence and development of different liver diseases, and discuss the potency and application of modulating the noncanonical NF-κB pathway for treatment of these liver diseases.

Keywords

Noncanonical NF-κB pathway, NF-κB-inducing kinase, Liver inflammation, Immune responses, Liver diseases

Journal of Clinical and Translational Hepatology 2021 vol. 9, 81-89  [ Html  ] [ PDF Full-text ]

© The Author(s) 2021. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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