Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 10 / 16 / 2021

Abstract

EDITORIAL

Ariadne’s Thread in the Network of Hepatocellular Carcinoma Immunobiology

John Koskinas* and Athanasios Armakolas

2nd Academic Department of Medicine, National and Kapodistrian University of Athens, Medical School Hippokration General Hospital, Athens, Greece
*Correspondence to: John Koskinas, 2nd Academic Department of Medicine, National and Kapodistrian University of Athens, Medical School Hippokration General Hospital, Athens, Greece. E-mail:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(3):279-280 DOI: 10.14218/JCTH.2021.00140
Received: April 13, 2021 Accepted: May 21, 2021 Published online: June 7, 2021

Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancers and represents a major global health problem. The main risk factors responsible for the development of HCC are chronic viral infections, non-alcoholic fatty liver disease, and alcohol-related liver disease, with wide geographical distribution.1 HCC development and growth involve multiple factors and pathways that lead to changes in gene expression, immune interactions and changes in the tumor microenvironment. In recent years, much progress has been made in understanding the mechanisms underlying tumor-immune system interactions and immunotherapy has been successfully applied to many tumors. Moreover, cancer-specific immune prognostic signatures have been evaluated in order to predict prognosis and response.2

Journal of Clinical and Translational Hepatology 2021 vol. 9, 279-280  [ Html  ] [ PDF Full-text ]

© 2021 Authors. This is an Open Access article distributed under the terms of the  Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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