Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 10 / 16 / 2021

Abstract

REVIEW ARTICLE

Nonalcoholic Fatty Liver Disease after Liver Transplant

Akshay Shetty1 , Fanny Giron2, Mukul K. Divatia3 , Muhammad I. Ahmad1, Sudha Kodali1 and David Victor1,*

1  Department of Medicine, Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital, Houston, TX, USA
2  Department of Medicine, Houston Methodist Hospital, Houston, TX, USA
3  Department of Pathology and Genomic Medicine, Weill Cornell Medical College, Houston Methodist Hospital, Houston, TX, USA
*Correspondence to: David Victor, Department of Medicine, Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital, Outpatient Center 22nd Floor, Houston, TX 77030, USA. ORCID: https://orcid.org/0000-0003-1414-3128. Tel: +1-713-790-3089, E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(3):428-435 DOI: 10.14218/JCTH.2020.00072
Received: July 26, 2020 Accepted: March 28, 2021 Published online: May 17, 2021

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the world. The rising prevalence of nonalcoholic steatohepatitis (NASH) has led to a 170% increase in NASH cirrhosis as the listing indication for liver transplantation from 2004 to 2013. As of 2018, NASH has overtaken hepatitis C as an indication for liver transplantation in the USA. After liver transplantation, the allograft often develops recurrent NAFLD among patients with known NASH cirrhosis. In addition to recurrent disease, de novo NAFLD has been reported in patients with other indications for liver transplantation. In this review, we will discuss the risk factors associated with recurrent and de novo NAFLD, natural course of the disease, and management strategies after liver transplantation.

Keywords

Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis, Post-transplant, Recurrent NAFLD, De novo NAFLD, Recurrent NASH, De novo NASH

Journal of Clinical and Translational Hepatology 2021 vol. 9, 428-435  [ Html  ] [ PDF Full-text ]

© 2021 Authors. This is an Open Access article distributed under the terms of the  Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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