Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 10 / 16 / 2021

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Original Article  

Mesenchymal Bone Marrow-derived Stem Cells Transplantation in Patients with HCV Related Liver Cirrhosis
Sviatlana P. Lukashyk, Vladimir M. Tsyrkunov, Yanina I. Isaykina, Oksana N. Romanova, Artur T. Shymanskiy, Olga V. Aleynikova and Rimma I. Kravchuk
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   217-221 Doi: 10.14218/JCTH.2014.00027

Review Articles  

Clinical Advances in Fibrosis Progression of Chronic Hepatitis B and C
Ye-Jiao Wu, Ming-Yi Xu and Lun-Gen Lu
Abstract ]   [ PDF Full-text ]  [ HTML Full-text ]   222-227 Doi: 10.14218/JCTH.2014.00029

Update on Alcohol and Viral Hepatitis
Stefano Gitto, Giovanni Vitale, Erica Villa and Pietro Andreone
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   228-233 Doi: 10.14218/JCTH.2014.00030

Thrombosis Associated with Viral Hepatitis
Luca Galli, Victor E. A. Gerdes, LuiginaGuasti and Alessandro Squizzato
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   234-239 Doi: 10.14218/JCTH.2014.00031

Hepatitis B and Hepatitis C Reactivation in the Biologic Era
Lizza Bojito-Marrero and Nikolaos Pyrsopoulos
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   240-246 Doi: 10.14218/JCTH.2014.00033

Treatment of Hepatitis C Virus Infection in Children Less than 12 Years of Age in Developing Countries
Sina Aziz
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   247-252 Doi: 10.14218/JCTH.2014.00034

Biomarker-based MicroRNA Therapeutic Strategies for Hepatocellular Carcinoma
Min Yao, Li Wang, Yao Yao, Hong-Bing Gu and Deng-Fu Yao
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   253-258 Doi: 10.14218/JCTH.2014.00020

Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus:What is New?
Ozgur Harmanci, Haldun Selcuk and Mehmet Haberal
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   259-265 Doi: 10.14218/JCTH.2014.00023

Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: a Review Featuring a Women’s Health Perspective
Rene´e
M. Marchioni Beery, Haleh Vaziri and Faripour Forouhar
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   266-284 Doi: 10.14218/JCTH.2014.00024

Update on Hepatitis B Virus Infection: Focus on Treatment
Stephanos J. Hadziyannis
Abstract ]  [ PDF Full-text ]  [ HTML Full-text ]   285-291 Doi: 10.14218/JCTH.2014.00026

 

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Original Article 

Mesenchymal Bone Marrow-derived Stem Cells Transplantation in Patients with HCV Related Liver Cirrhosis
Sviatlana P. Lukashyk, Vladimir M. Tsyrkunov, Yanina I. Isaykina, Oksana N. Romanova, Artur T. Shymanskiy, Olga V. Aleynikova and Rimma I. Kravchuk
Abstract ]   [ PDF Full-text ]   217-221 Doi: 10.14218/JCTH.2014.00027

Review Articles  

Clinical Advances in Fibrosis Progression of Chronic Hepatitis B and C
Ye-Jiao Wu, Ming-Yi Xu and Lun-Gen Lu
Abstract ]   [ PDF Full-text ]   222-227 Doi: 10.14218/JCTH.2014.00029

Update on Alcohol and Viral Hepatitis
Stefano Gitto, Giovanni Vitale, Erica Villa and Pietro Andreone
Abstract ]   [ PDF Full-text ]   228-233 Doi: 10.14218/JCTH.2014.00030

Thrombosis Associated with Viral Hepatitis
Luca Galli, Victor E. A. Gerdes, Luigina Guasti and Alessandro Squizzato
Abstract ]   [ PDF Full-text ]   234-239 Doi: 10.14218/JCTH.2014.00031

Hepatitis B and Hepatitis C Reactivation in the Biologic Era
Lizza Bojito-Marrero and Nikolaos Pyrsopoulos
Abstract ]   [ PDF Full-text ]   240-246 Doi: 10.14218/JCTH.2014.00033

Treatment of Hepatitis C Virus Infection in Children Less than 12 Years of Age in Developing Countries
Sina Aziz
Abstract ]   [ PDF Full-text ]   247-252 Doi: 10.14218/JCTH.2014.00034

Biomarker-based MicroRNA Therapeutic Strategies for Hepatocellular Carcinoma
Min Yao, Li Wang, Yao Yao, Hong-Bing Gu and Deng-Fu Yao
Abstract ]   [ PDF Full-text ]   253-258 Doi: 10.14218/JCTH.2014.00020

Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
Ozgur Harmanci, Haldun Selcuk and Mehmet Haberal
Abstract ]   [ PDF Full-text ]   259-265 Doi: 10.14218/JCTH.2014.00023

Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: a Review Featuring a Women’s Health Perspective
Rene´e
M. Marchioni Beery, Haleh Vaziri and Faripour Forouhar
Abstract ]   [ PDF Full-text ]   266-284 Doi: 10.14218/JCTH.2014.00024

Update on Hepatitis B Virus Infection: Focus on Treatment
Stephanos J. Hadziyannis
Abstract ]   [ PDF Full-text ]   285-291 Doi: 10.14218/JCTH.2014.00026

  

Mesenchymal Bone Marrow-derived Stem Cells Transplantation in Patients with HCV Related Liver Cirrhosis

Sviatlana P. Lukashyk1, Vladimir M. Tsyrkunov*2, Yanina I. Isaykina3, Oksana N. Romanova3Artur T. Shymanskiy3, Olga V. Aleynikova3 and Rimma I. Kravchuk4

1Department of Infection Diseases, The Belarusian State Medical University, Minsk, Republic of Belarus; 2Department of Infection Diseases, The Grodno State Medical University, Grodno, Republic of Belarus; 3Cell biotechnology and cytotherapy laboratory, The Republican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, Republic of Belarus; 4Central Scientific Research Laboratory, The Grodno State Medical University, Grodno, Republic of Belarus

Abstract

Background and Aims: To evaluate the effect of intraparenchymal transplantation of mesenchymal bone marrow-derived stem cells (BMSCs) in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). Methods: Mononuclear cells were isolated from patient bone marrow and were passaged several times in vitro in order to reach the required volume. Attributes of the BMSCs were evaluated by the presence of the surface markers CD105+, CD90+, and CD73+. Cells from each passage were evaluated for sterility, and they were transplanted intraparenchymally into liver tissue. Clinical and laboratory data were evaluated and morphological studies of liver biopsy were performed prior to and 6 months after transplantation. Results: On clinical evaluation, the general state of these patients was improved at 1 month following transplantation of BMSCs. At 1 and 6 months post-transplantation, jaundice was absent in four (67%) patients. After 6 months, functional hepatic indices were improved, i.e. decrease of ALT and AST activity and bilirubin level. However, these decreases were not statistically different (P>0.05). Expression of CD34 and a-SMA in liver biopsy samples were decreased at 6 months after transplantation, consistent with structural improvements in mitochondria and nuclear compartments. Conclusions:Intraparenchymal transplantation of autologous BMSCs improved the functional condition of the liver, stimulated reparative processes in hepatocytes, and decreased extracellular matrix protein (EMP) count in hepatic tissues of patients with LC. It was well tolerated and was not associated with any complications both during and after BMSC transplantation.

 

Doi: 10.14218/JCTH.2014.00027
Journal of Clinical and Translational Hepatology 2014 vol. 2 Pages:217-221 [PDF Full-text ]

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