Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 12 / 09 / 2021

Abstract

Update on Alcohol and Viral Hepatitis

Stefano Gitto1, Giovanni Vitale2, Erica Villa1 and PietroAndreone*2

1Dipartimento di Gastroenterologia, AziendaOspedaliero-Universitaria& University of Modena and Reggio Emilia, Modena, Italy; 2Dipartimento di ScienzeMediche e Chirurgiche, University of Bologna and Dipartimentodell’ApparatoDigerente, AziendaOspedaliero-Universitaria di Bologna, PoliclinicoSant’Orsola Malpighi, Bologna, Italy

Abstract

Alcohol consumption is often associated with viral hepatitis.Although alcohol is known to worsen viral liver disease, theinteractions between alcohol and viral hepatitis are not fullyunderstood. Molecular alterations in the liver due to alcoholand viral hepatitis include effects on viral replication,increased oxidative stress, cytotoxicity, and a weakenedimmune response. Clinically, alcohol enhances disease progressionand favors induction of primitive liver neoplasm. Theuse of new antivirals for hepatitis C and well-establisheddrugs for hepatitis B will determine how viral hepatitis can becontrolled in a large percentage of these patients. However,alcohol-related liver disease continues to represent a barrierfor access to antivirals, and it remains an unresolved healthissue.

Doi: 10.14218/JCTH.2014.00030
Journal of Clinical and Translational Hepatology 2014 vol. 2 Pages: 228-233 
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