Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Friday, 08 / 18 / 2017

Articles

Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

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Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

Saleh Elwir* and Robert S. Rahimi

Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA

*Correspondence to: Saleh Elwir, Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, 3410 Worth Street, Suite 950, Dallas, TX 75246, USA. +1-214-820-8500, Fax: +1-214-820-0993, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2017;5(2):142-151 DOI: 10.14218/JCTH.2016.00069
Received: November 24, 2016 Accepted: March 24, 2017 Published online: May 4, 2017

Abstract

Hepatic encephalopathy is a spectrum of reversible neuropsychiatric abnormalities, seen in patients with liver dysfunction and/or portosystemic shunting. One of the most debilitating complications of cirrhosis, encephalopathy affects 30–45% of cirrhotics. In addition to significantly affecting the lives of patients and their caregivers, it is also associated with increased morbidity and mortality as well as significant utilization of health care resources. In this paper, we provide an overview on the pathophysiology, diagnosis, management and newer therapies of hepatic encephalopathy.

Keywords

Hepatic encephalopathy, Cirrhosis, Lactulose, Rifaximin

 

Journal of Clinical and Translational Hepatology 2017 vol. 5 Html ] [ PDF Full-text ]

© The Authors 2017. This article is published under the terms of the Creative Commons Attribution-Noncommercial (CC BY-NC) License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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