Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 09 / 26 / 2020

Articles

Abstract

ORIGINAL ARTICLE

Effect of Exercise on NAFLD and Its Risk Factors: Comparison of Moderate versus Low Intensity Exercise

Preetam Nath1, Manas Kumar Panigrahi2, Manoj Kumar Sahu3, Jimmy Narayan3Ranjan Kumar Sahoo4, Ananya Apurba Patra4, Satyaswarup Jena5, Arun Kumar Patnaik6, Anjan Jena6 and  Shivaram Prasad Singh*,7

1  Department of Gastroenterology & Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India
2  Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
3  Department of Gastroenterology, IMS and SUM Hospital, Bhubaneswar, Odisha, India
4  Department of Radiodiagnosis & Imaging, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India
5  Department of Radiology, IMS and SUM Hospital, Bhubaneswar, Odisha, India
6  Dispensary, Biju Patnaik State Police Academy, Bhubaneswar, Odisha, India
7  Department of Gastroenterology, S.C.B. Medical College, 753007 Cuttack, Odisha, India
*Correspondence to: Shivaram Prasad Singh, Department of Gastroenterology, SCB Medical College, Cuttack 753007, Orissa, India. Tel: +91-671-2505466, +91-671-2323624, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2020;8(2):120-126 DOI: 10.14218/JCTH.2019.00012
Received: March 10, 2019 Accepted: April 1, 2020 Published onlineApril 25, 2020

Abstract

Background and Aims: Lifestyle (exercise and dietary) modification is the mainstay of treatment for non-alcoholic fatty liver disease (NAFLD). However, there is paucity of data on effect of intensity of exercise in management of NAFLD, and we aimed to study the effect of variable intensities of exercise on NAFLD.

 

Methods: The study was performed in the Department of Gastroenterology of the SCB Medical College, Cuttack and the Biju Patnaik State Police Academy, Bhubaneswar. The subjects were police trainees [18 in a moderate intensity exercise group (MIG) and 19 in a low intensity exercise group (LIG)] recruited for a 6-month physical training course (261.8 Kcalorie, 3.6 metabolic equivalent in MIG and 153.6 Kcalorie, 2.1 metabolic equivalent in LIG). NAFLD was diagnosed by ultrasonography, with exclusion of all secondary causes of steatosis. All participants were evaluated by anthropometry (weight, height, body mass index (BMI), waist circumference), assessed for blood pressure and biochemical parameters (blood glucose, liver function test, lipid profile, serum insulin), and subjected to transabdominal ultrasonography before and after 6 months of physical training, and the results were compared.

 

Results: Both the groups had similar BMI, fasting plasma glucose, AST, gamma-glutamyl transpeptidase, insulin, and homeostatic model assessment-insulin resistance (known as HOMA-IR) (p>0.05). However, subjects in the LIG were older and had lower alanine transaminase, higher triglycerides and lower high-density lipoproteins than MIG subjects. There was a significant reduction in BMI (27.0±2.1 to 26.8±2.0; p=0.001), fasting blood glucose (106.7±21.6 to 85.8±19.0; p<0.001), serum triglycerides (167.5±56.7 to 124.6±63.5; p=0.017), total cholesterol (216.8±29.2 to 196.7±26.6; p=0.037), low-density lipoprotein cholesterol (134.6±21.4 to 130.5±21.9; p=0.010), serum aspartate transaminase (39.3±32.2 to 30.9±11.4; p<0.001), serum alanine transaminase (56.6±28.7 to 33.0±11.3; p<0.001) and HOMA-IR (2.63±2.66 to 1.70±2.59; p<0.001) in the MIG. However, changes in these parameters in the LIG were non-significant. Hepatic steatosis regressed in 66.7% of the NAFLD subjects in the MIG but in only 26.3% of the LIG NAFLD subjects (p=0.030).

 

Conclusions: Moderate rather than low intensity physical activity causes significant improvement in BMI, serum triglycerides, cholesterol, serum transaminases and HOMA-IR, and regression of ultrasonographic fatty change in liver among NAFLD subjects.

 

Keywords

Exercise, NAFLD, Intensity, Physical activity

Journal of Clinical and Translational Hepatology 2020 vol. 8, 120-126  [ Html  ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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