Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Tuesday, 06 / 15 / 2021



Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis Overlap Syndrome: A Review

Sheena Mago*, and George Y. Wu

Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA
*Correspondence to: Sheena Mago, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2020;8(3):336-346 DOI: 10.14218/JCTH.2020.00036
Received: April 24, 2020 Accepted: July 24, 2020 Published onlineAugust 24, 2020


Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are slow progressive diseases which have been increasing in prevalence. The pathogeneses of PBC and PSC are incompletely understood but the underlying mechanisms appear to be fundamentally autoimmune in origin. Although PBC and PSC appear to be separate entities, overlap has been described. Diagnosis depends on a combination of serological markers, imaging, and pathological criteria. The mainstay of treatment has been ursodeoxycholic acid and in some cases of extrahepatic biliary obstruction and overlap disorder, endoscopic retrograde cholangiopancreatography has been useful.


Primary sclerosing cholangitis, Primary biliary cirrhosis, Overlap syndrome

Journal of Clinical and Translational Hepatology 2020 vol. 8, 336-346  [ Html  ] [ PDF Full-text ]

© The Authors 2020. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.


You are here: Home