Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 01 / 25 / 2021

Articles

REVIEW ARTICLE

Macrophage Phenotypes and Hepatitis B Virus Infection

Yujia Li1, Shilin Li1Xiaoqiong Duan1Chunhui Yang1Min Xu1 and Limin Chen*,1,2

1  Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China
2  Toronto General Research Institute, University of Toronto, Toronto, ON M5G 1L6, Canada
*Correspondence to: Limin Chen, Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, 26 Huacai Street, Chengdu, Sichuan 610052, China. Tel: +86-28-61648530, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2020;8(4):424-431 DOI: 10.14218/JCTH.2020.00046
Received: May 14, 2020 Accepted: September 6, 2020 Published online: October 10, 2020

Abstract

Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is becoming increasingly apparent that Kupffer cells (KCs), the largest population of resident and monocyte-derived macrophages in the liver, contribute to HBV infection in various aspects. These cells play an important role not only in the anti-HBV immunity including virus recognition, cytokine production to directly inhibit viral replication and recruitment and activation of other immune cells involved in virus clearance but also in HBV outcome and progression, such as persistent infection and development of end-stage liver diseases. Since liver macrophages play multiple roles in HBV infection, they are directly targeted by HBV to benefit its life cycle. In the present review, we briefly outline the current advances of research of macrophages, especially the studies of their phenotypes, in chronic HBV infection.

Keywords

Hepatitis B virus, Chronic HBV infection, Macrophage, Phenotype

Journal of Clinical and Translational Hepatology 2020 vol. 8, 424-431  [ Html  ] [ PDF Full-text ]

© The Authors 2020. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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