Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Friday, 05 / 14 / 2021



Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis

Qiaoling Wang†,1,2, Binxia Chang†,2, Xiaoyan Li3 and Zhengsheng Zou*,1,2

1  Peking University, 302 Clinical Medical School, Beijing, China
2  Diagnosis and Treatment Center for Non-Infectious Liver Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
Anhui Medical University, Hefei, Anhui, China
†  These authors contributed equally to this paper.
*Correspondence to: Zhengsheng Zou, The Center for Diagnosis and Treatment of Non-Infectious Liver Disease, The General Hospital of Chinese People’s Liberation Army No. 5 Medical Science Center, No. 100 Xisihuan Middle Road, Beijing 100039, China, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(1):90-98 DOI: 10.14218/JCTH.2020.00104
Received: November 9 2020 Accepted: December 18, 2020 Published online: January 4, 2021


Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease. ALDH2 gene mutations exist in about 8% of the world’s population, with the incidence reaching 45% in East Asia. The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde, facilitating the progression of other liver diseases, including non-alcoholic fatty liver diseases, viral hepatitis and hepatocellular carcinoma, through adduct formation and inflammatory responses. In this review, we seek to summarize recent research progress on the correlation between ALDH2 gene polymorphism and multiple liver diseases, with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.


Aldehyde dehydrogenase 2, Gene polymorphisms, Alcoholic liver disease, Non-alcoholic fatty liver disease, Viral hepatitis, Hepatocellular carcinoma

Journal of Clinical and Translational Hepatology 2021 vol. 9, 90-98  [ Html  ] [ PDF Full-text ]

© The Author(s) 2021. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.


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