Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 03 / 08 / 2021

Articles

REVIEW ARTICLE

An Ecological Evaluation of Vinyl Chloride Exposure and Liver Cancer Incidence and Mortality in Texas

Kevin M. Towle*,1, Stacey M. Benson2, Natalie S. Egnot2 and Gary M. Marsh2

1  Cardno ChemRisk, San Francisco, CA, USA
2  Cardno ChemRisk, Pittsburgh, PA, USA
*Correspondence to: Gary Marsh, Cardno ChemRisk, 20 Stanwix Street Suite 505, Pittsburgh, PA 15222, USA. Tel: +1-412-694-7051, Fax: +1-415-896-2444, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(1):99-105 DOI: 10.14218/JCTH.2020.00073
Received: July 26, 2020 Accepted: November 27, 2020 Published online: December 30, 2020

Abstract

The goal of this analysis was to evaluate the association between county-level ambient vinyl chloride (VC) and county-level liver cancer incidence and mortality rates in Texas. Modeled county-level ambient VC data were obtained from the National Air Toxics Assessment. Age-adjusted county-level liver cancer incidence rates were abstracted from the Texas Cancer Registry and age-standardized county-level liver cancer mortality rates were obtained from the peer-reviewed literature. Multivariable imputation was utilized to impute incidence rates in counties with suppressed liver cancer incidence rates. Negative binomial and Poisson regression models were utilized to evaluate the association between county-level ambient VC and county-level liver cancer incidence and mortality rates, respectively, adjusted for county-level heavy drinking prevalence, hepatitis mortality rates, median income, and race (percent Hispanic). County-level ambient VC was not associated with county-level liver cancer incidence or mortality rates. Specifically, when compared to the lowest tertile of ambient VC, the middle (relative risk [RR]: 1.06, 95% confidence interval [CI]: 0.95–1.19) and highest (RR: 1.03, 95% CI: 0.90–1.17) tertiles of ambient VC were not associated with liver cancer incidence. Similarly, county-level ambient VC in the middle (RR: 0.95, 95% CI: 0.85–1.05) and highest (RR: 0.93, 95% CI: 0.82–1.05) tertiles were not associated with liver cancer mortality. This analysis suggests that county-level ambient VC is not associated with liver cancer incidence or mortality in Texas. Our study provides novel results regarding liver cancer risk from low-level non-occupational exposure to ambient VC.

Keywords

Vinyl chloride, Liver cancer, Epidemiology, Incidence

Journal of Clinical and Translational Hepatology 2021 vol. 9, 99-105  [ Html  ] [ PDF Full-text ]

© The Author(s) 2021. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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