Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 03 / 08 / 2021

Articles

REVIEW ARTICLE

Cytomegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts

Teresa Da Cunha*,1 and George Y. Wu1,2

1  Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA
2  Current address: Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
*Correspondence to: Teresa Da Cunha, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. Tel: +1-860-706-2133, Fax: +1-860-679-3159, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(1):106-115 DOI: 10.14218/JCTH.2020.00088
Received: September 15, 2020 Accepted: December 8, 2020 Published online: January 4, 2021

Abstract

Human cytomegalovirus (HCMV) infection is common and affects between 40–100% of the worldwide population. However, the majority of cases are asymptomatic and when severe disease occurs, it is usually restricted to immunocompromised patients. Liver involvement by HCMV differs significantly, accordingly to the immune status of the host. In immunocompromised patients, particularly liver transplant patients, it often causes clinically significant hepatitis. On the other hand, in immunocompetent patients, HCMV hepatitis requiring hospitalization is extremely rare. This review aims to appraise studies regarding the pathophysiology of HCMV hepatitis, including mechanisms of latency and reactivation and its contribution to disease development, clinical presentation, diagnostic modalities and treatment, with a focus on comparing different aspects between immunocompromised and immunocompetent hosts.

Keywords

CMV hepatitis, Cytomegalovirus hepatitis, Cytomegalovirus hepatitis immunocompetent, Cytomegalovirus hepatitis immunocompromised

Journal of Clinical and Translational Hepatology 2021 vol. 9, 106-115  [ Html  ] [ PDF Full-text ]

© The Author(s) 2021. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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