Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 05 / 13 / 2021

Articles

Abstract

ORIGINAL ARTICLE

Predictive Model of Ursodeoxycholic Acid Treatment Response in Primary Biliary Cholangitis

Yanyun Shu , Yuhu Song , Tao Bai , Xiaoli Pan , Haitao Shang , Ling Yang , Jin Ye* and Fan Du*

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
*Correspondence to: Jin Ye and Fan Du, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. ORCID: Jin Ye: https://orcid.org/0000-0002-1521-1746, Fan Du: https://orcid.org/0000-0003-2704-2131 . Tel: +86-27-85726678, E-mail:  This email address is being protected from spambots. You need JavaScript enabled to view it. (JY); Tel: +86-27-85726601, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. (FD).

Journal of Clinical and Translational Hepatology 2021;9(2):187-193 DOI: 10.14218/JCTH.2020.00127
Received: November 24, 2020 Accepted: February 13, 2021 Published online: March 4, 2021

Abstract

Background and Aims: Although ursodeoxycholic acid (UDCA) treatment in primary biliary cholangitis is effective in many patients, there are still many people who respond poorly to it. Identifying and intervening these patients early is important. Therefore, exploring the risk factors and proposing a predictor index to predict the UDCA treatment nonresponse earlier among primary biliary cholangitis patients were the aims of this research.

Methods: A total of 135 primary biliary cholangitis patients treated with UDCA (13–15 mg/kg/d) were enrolled in this retrospective study. The response to treatment was evaluated based on Paris I criteria. The univariate and logistic multivariate regression analyses were adopted to determine the independent risk factors and propose a predictor index. Receiver operating characteristic curve was used to evaluate the predictive ability of the predictor index.

Results: Total bilirubin, albumin, globulin, immunoglobin M, and aspartate aminotransferase-to-platelet ratio index were the five independent risk factors associating with early biochemical nonresponse to UDCA treatment. Based on these factors, we established a predictor index with the predictive value being 0.886 (sensitivity: 82.80%, specificity: 84.40%).

Conclusions: We developed a predictor index that had an accurate prediction of the early biochemical nonresponse to UDCA treatment, which is expected to provide valuable information for the high-risk group before treatment begins.

Keywords

Primary biliary cholangitis, Therapy, Risk factors, Statistical model

Journal of Clinical and Translational Hepatology 2021 vol. 9, 187-193  [ Html  ] [ PDF Full-text ]

© 2021 Authors. This is an Open Access article distributed under the terms of the  Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 

 logo

You are here: Home