Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 12 / 09 / 2021

Articles

Abstract

ORIGINAL ARTICLE

Development of a Novel Endovascular Brachytherapy Stent: A Proof-of-concept Study

Nan Du1,2,# , Jingqin Ma1,2,# , Zihan Zhang1,2 , Yongjie Zhou1,2 , Minjie Yang1,2 , Wen Zhang1,2 , Jianjun Luo1,2,* and Zhiping Yan1,2,*

1  Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China
2  Shanghai Institution of Medical Imaging, Shanghai, China
#These two authors contributed equally to this study.
*Correspondence to:Zhiping Yan and Jianjun Luo, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. ORCID: https://orcid.org/0000-0001-7907-435X (ZY), https://orcid.org/0000-0003-4942-0439 (JL). Tel: +86-13681971205, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. (ZY); Tel: +86-13801924777, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. (JL)

Journal of Clinical and Translational Hepatology 2021;9(5):711-718 DOI: 10.14218/JCTH.2020.00128
Received:November 24, 2020 Accepted:April 7, 2021 Published online:July 7, 2021

Abstract

Background and Aims:Endovascular implantation of iodine-125 (125I) seeds strand combined with stent is an effective method of treatment for portal vein tumor thrombosis. The aim of this study was to develop a novel endovascular brachytherapy stent (EVB-Stent) and to evaluate its feasibility of use.

Methods:An EVB-Stent was implanted into the main portal vein (MPV) in a live porcine model via the percutaneous transhepatic route. Blood samples were collected and tested before and after operation, as well as before euthanasia. Single-photon emission computed tomography (SPECT) combined with CT (SPECT/CT) scan were performed directly after operation and CT scan was performed 2 months after implantation. After the CT scan was performed, all animals were euthanized and histologically examined.

Results:The novel stent was successfully positioned in all six pigs. No deterioration of liver function was observed during the 2-month follow-up period. SPECT/CT revealed the uniform distribution of radiation around the seeds strand, and the hottest spot was near the center of the MPV. The patency of the stented MPV was confirmed using CT scans. The tissue-accumulated absorbed dose was 31,822.11 mGy at 10 mm transversely away from the midpoint of the 125I seeds strand, with a half-life of 59.4 days. Pathological examination results showed no significant atrophy or inflammation of adjunct liver tissue, and no obvious intima thickening or thrombosis were detected in the stented MPV.

Conclusions:A liver porcine model was used to demonstrate that the transhepatic placement of a novel endovascular brachytherapy stent, EVB-Stent, is both technically feasible and safe.

Keywords

Portal vein tumor, Tumor thrombus, Brachytherapy, Stent, Iodine-125 seeds strand

Journal of Clinical and Translational Hepatology 2021 vol. 9, 711-718  [ Html  ] [ PDF Full-text ]

© 2021 Authors. This is an Open Access article distributed under the terms of the  Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 

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