Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

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Articles

Volume 7 Issue 1, 2019

Category: Vol 7 Issue 1 Published on 14 October 2019 Super User
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Table of Contents

Editorial

Hepatocellular Carcinoma Surveillance and Treatment: A Way to Reduce Cancer-related Mortality in Cirrhotic Patients
Xiangjun Qian, Xiaotong Yan, Xiangwei Zhai, Ni Li, Chunfeng Qu, Fengmin Lu
Abstract ] [ Html ] [ PDF Full-text ] 1-2 Doi: 10.14218/JCTH.2019.00002

Original Article

A Meta-analysis of the Value of vWF in the Diagnosis of Liver Cirrhosis with Portal Hypertension
Xiang-Chun Ding, Wan-Long Ma, Ming-Kun Li, Shuai-Wei Liu, Xiao-Yan Liu, Long Hai, Xia Luo, Yan-Chao Hu, Li-Na Ma
Abstract ] [ Html ] [ PDF Full-text ] 3-8 Doi: 10.14218/JCTH.2018.00036

Patients with Cirrhosis of Liver Operated for Non-transplant Surgery: A Retrospective Analysis
Kishore Kumar Kuduva Subramanian, Manish Tandon, Chandra Kant Pandey, Priyanka Jain
Abstract  ] [ Html ] [ PDF Full-text ] 9-14 Doi: 10.14218/JCTH.2018.00043

High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases
Krishnasamy Narayanasamy, Rajendran Karthick, A. Koodal Raj
Abstract ] [ Html ] [ PDF Full-text ] 15-20 Doi: 10.14218/JCTH.2018.00018

Liver Fibrosis Helps to Distinguish Autoimmune Hepatitis from DILI with Autoimmune Features: A Review of Twenty Cases
Christopher A. Febres-Aldana, Sarah Alghamdi, Kritika Krishnamurthy, Robert J. Poppiti
Abstract ] [ Html ] [ PDF Full-text ] 21-26 Doi: 10.14218/JCTH.2018.00053

TM6SF2 E167K Variant Overexpression Promotes Expression of Inflammatory Cytokines in the HCC Cell Line HEPA 1-6
Shuixian Du, Songling Liao, Shousheng Liu, Yongning Xin
Abstract ] [ Html ] [ PDF Full-text ] 27-31 Doi: 10.14218/JCTH.2018.00055

Case Control Study of Post-endoscopic Variceal Ligation Bleeding Ulcers in Severe Liver Disease: Outcomes and Management
Kapil D. Jamwal, Rakhi Maiwall, Manoj K. Sharma, Guresh Kumar, Shiv K. Sarin
Abstract ] [ Html ] [ PDF Full-text ] 32-39 Doi: 10.14218/JCTH.2018.00059

Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model
Fangfang Li, Juan Zhou, Yi Li, Kewei Sun, Jun Chen
Abstract ] [ Html ] [ PDF Full-text ] 40-45 Doi: 10.14218/JCTH.2018.00052

Methods Article

An Improved Method for Preparation of Uniform and Functional Mitochondria from Fresh Liver
Nagham Khouri Farah, Xiaocong Liu, Catherine H. Wu, George Y. Wu
Abstract ] [ Html ] [ PDF Full-text ] 46-50 Doi: 10.14218/JCTH.2018.00064

Review Article

Procalcitonin and Liver Disease: A Literature Review
Ruolin Dong, Bo Wan, Su Lin, Mingfang Wang, Jiaofeng Huang, Yinlian Wu, Yilong Wu, Nanwen Zhang, Yueyong Zhu
Abstract ] [ Html ] [ PDF Full-text ] 51-55 Doi: 10.14218/JCTH.2018.00012

Fatty Liver Disease and Gut Microbiota: A Comprehensive Update
Lyna Campo, Sara Eiseler, Tehilla Apfel, Nikolaos Pyrsopoulos
Abstract ] [ Html ] [ PDF Full-text ] 56-60 Doi: 10.14218/JCTH.2018.00008

A Review on the Management of Biliary Complications after Orthotopic Liver Transplantation
Brian T. Moy, John W. Birk
Abstract ] [ Html ] [ PDF Full-text ] 61-71 Doi: 10.14218/JCTH.2018.00028

Hepatocellular Carcinoma: State of the Art Imaging and Recent Advances
Patrick J. Navin, Sudhakar K. Venkatesh
Abstract ] [ Html ] [ PDF Full-text ] 72-85 Doi: 10.14218/JCTH.2018.00032

Mechanisms of Hepatic Cholestatic Drug Injury
Tea Omanović Kolarić, Vjera Ninčević, Robert Smolić, Martina Smolić, George Y Wu
Abstract ] [ Html ] [ PDF Full-text ] 86-92 Doi: 10.14218/JCTH.2018.00042

Case Report

Liver Abscess in a Pediatric Patient with Ulcerative Colitis: A Case Presentation
Daniel F. Castillo, Ricardo Caicedo, Vani Gopalareddy
Abstract ] [ Html ] [ PDF Full-text ] 93-96 Doi: 10.14218/JCTH.2018.00045

Liver Abscess in a Pediatric Patient with Ulcerative Colitis: A Case Presentation

Category: Vol 7 Issue 1 Published on 11 April 2019
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CASE REPORT

Liver Abscess in a Pediatric Patient with Ulcerative Colitis: A Case Presentation

Daniel F. Castillo*,1, Ricardo Caicedo2 and Vani Gopalareddy2

1Department of Pediatrics, Atrium Health- Levine Children’s Hospital, Charlotte, NC, USA
2Department of Pediatric Gastroenterology, Atrium Health- Levine Children’s Hospital, Charlotte, NC, USA
*Correspondence to: Daniel F. Castillo, Department of Pediatrics, Atrium Health- Levine Children’s Hospital, 1000 Blythe Blvd, Charlotte, NC 28203, USA. Tel: +1-407-314-5294, Fax: +1-704-381-6841, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(1):93-96 DOI: 10.14218/JCTH.2018.00045
Received: July 28, 2018 Accepted: January 7, 2019 Published online: March 4, 2019

Abstract

Hepatic abscesses are an uncommon extra-intestinal manifestation of inflammatory bowel disease, the incidence of which has been estimated to be approximately 7 per 10,000 patients with inflammatory bowel disease. It is unclear whether patients with Crohn’s disease or patients with ulcerative colitis (UC) are at higher risk of developing this complication. Based on case reports, most cases are found in Crohn’s disease; however, a recent cohort study showed an increased risk in UC instead. Hepatic abscesses in the pediatric population are rare, and there have been no reported cases of hepatic abscesses in a pediatric patient with UC. We describe herein a pediatric patient with UC who developed hepatic abscesses and portal vein thrombosis. This patient also had an extended time in remission from his UC despite being off of immunosuppressive therapies, and we speculate on how his clinical course and treatment strategies may have contributed to this.

Keywords

Ulcerative colitis, IBD, Liver abscess

 

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 93-96  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

Mechanisms of Hepatic Cholestatic Drug Injury

Category: Vol 7 Issue 1 Published on 11 April 2019 Super User
Hits: 1647

REVIEW ARTICLE

Mechanisms of Hepatic Cholestatic Drug Injury

Tea Omanović Kolarić1,2, Vjera Ninčević1,2, Robert Smolić1, Martina Smolić*1,2 and George Y Wu3

1Department of Pharmacology, Faculty of Medicine Osijek, Osijek, Croatia
2Department of Pharmacology, Faculty of Dental Medicine and Health, Osijek, Croatia
3Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA
*Correspondence to: Martina Smolic, Department of Pharmacology, Faculty of Medicine Osijek, J. Huttlera 4, Osijek 31000, Croatia. Tel: +38-531512800, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(1):86-92 DOI: 10.14218/JCTH.2018.00042
Received: July 5, 2018 Accepted: February 8, 2019 Published online: March 25, 2019

Abstract

Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.

Keywords

Drug-induced liver injury, Bile acids, Cholestasis

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 86-92  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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