Stratified Platelet-to-lymphocyte Ratio: A Novel Target for Prognostic Prediction of Hepatocellular Carcinoma after Curative Liver Resection

  • Gui-Qian Huang‡,1,2,
  • Ji-Na Zheng‡,1,3,
  • Tian-Tian Zou‡,1,4,
  • Yi-Ran Chen1,3,
  • Ke-Qing Shi1,5,
  • Sven Van Poucke6,
  • Zhang Cheng1,3,
  • Lu-Yi Ruan1,3 and
  • Ming-Hua Zheng*,1,5
 Author information
Journal of Clinical and Translational Hepatology 2017;5(1):35-42

DOI: 10.14218/JCTH.2016.00035


Background and Aims: Platelet-to-lymphocyte ratio (PLR) has been shown to predict prognosis of cancers. We aimed to evaluate the prognostic value of stratification of PLR in patients after curative liver resection (CLR) for hepatocellular carcinoma (HCC).

Methods: A total of 1804 patients who underwent CLR for suspected HCC between January 2007 and January 2014 were screened for the study. All of the patients were categorized into equal tertiles according to the number of patients and the distribution of PLR. Prognostic significance was determined for overall survival (OS) and was assessed using Kaplan–Meier analysis. Univariate and multivariate Cox proportional hazard regression analyses were evaluated for association of all independent parameters with disease prognosis.

Results: The optimal cut-off points of preoperative PLR were: (T1) 11.98–75.00, (T2) 75.00–113.33 and (T3) 113.33–567.50. There were obvious differences in each PLR tertile with mortality within 36 months of CLR (plog-rank < 0.001). Multivariable analysis suggested that the level of PLR (HR = 1.004, 95%CI: 1.001–1.008, p = 0.006), portal vein thrombosis (HR = 3.406, 95%CI: 1.185–9.794, p = 0.023), number of nodules (HR = 1.810, 95%CI: 1.345–2.437, p < 0.001), Child-Turcotte-Pugh score (HR = 1.741, 95%CI: 1.129–2.684, p = 0.012) and microvascular invasion (HR = 2.730, 95%CI: 1.777–4.196, p < 0.001) were significant predictors of mortality. Kaplan–Meier analysis of overall survival (OS) demonstrated that each PLR tertile showed a progressively worse OS and apparent separation (plog-rank = 0.016). The highest 5-year OS rate following CLR (58%) was revealed in tertile 1. In contrast, the lowest 5-year OS rate (30%) was revealed in tertile 3.

Conclusion: Stratified preoperative PLR could strengthen the predictive power for OS in HCC patients with CLR.


Platelet-to-lymphocyte ratio, Hepatocellular carcinoma, Curative liver resection, Overall survival


Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Recently, there have been approximately 750,000 new cases of liver cancer reported per year.1,2 For men, it is the second leading cause of cancer death worldwide in less developed countries. In more developed countries, it is the sixth leading cause of cancer death among men.3 At present, based on limitations for a more widespread application of liver transplantation for HCC patients (shortage of donor organs, higher perioperative risk, high cost and long-term immunosuppression), hepatectomy is widely accepted as the first treatment option and provides a radical therapy in patients with early stages of HCC.4,5

With appropriate surgical techniques and perioperative management to preserve function of the liver remnant, HCC can be resected safely and with very low operative morbidity and mortality rates.6,7 However, some studies have indicated that linked to the high recurrence rate, patients’ long-term prognosis after radical resection remains poor.4,8 Therefore, it is necessary to monitor patients for progression of HCC by controlling tumor recurrence, ultimately prolonging the survival period in HCC patients after curative liver resection (CLR).

Currently, some studies have shown that genetic, biological aggressiveness and environmental factors are contributory risk factors for the progression and development of HCC.9,10 In addition, numerous pathological features have been identified as prognostic indicators for HCC patients, such as tumor burden, the presence of hepatic vascular invasion, portal vein thrombosis, serum bilirubin, C-reactive protein and the elevated serum levels of alpha-fetoprotein (AFP).1116 Previous studies have demonstrated that systemic inflammation is related to poor prognosis and increased tumor progression through up-regulation of cytokines in a variety of cancers.17,18 As biomarkers of systemic inflammation, elevated neutrophil-lymphocyte ratio (NLR) and absolute monocyte counts have demonstrated a potential influence for guiding the clinical management of cancer patients.19

Recently, the platelet-to-lymphocyte ratio (PLR), a marker of systemic inflammation, (ratio of the absolute platelet and lymphocyte counts), has been reported to be associated with the progression of various tumor types, including pancreatic ductal adenocarcinoma, epithelial ovarian cancer, and metastatic renal cell cancer.2022 However, there is conflicting data regarding the ability of predicting prognosis of HCC patients with PLR.23 Li et al.24 demonstrated that elevated PLR was associated with aggressive tumor behavior, and can be identified as a poor independent prognostic factor in advanced HCC patients. However, other studies fail to find correlation between clinical outcome and the level of PLR in HCC patients.25,26 As such, the current opinion on the prognostic role of PLR for HCC is still controversial, and to date there have been no reports regarding PLR in HCC patients undergoing CLR with stratification in order to predict overall survival (OS).

Therefore, the purpose of this study was to use stratification with preoperative PLR to assess the prognostic impact on OS for patients who underwent CLR for suspected HCC.


Study design

Data was collected from the First Affiliated Hospital of Wenzhou Medical University clinical database, all patients were sampled consecutively from PLR records for suspected HCC between January 2007 and January 2014.

PLR was defined as the absolute platelet count divided by the absolute lymphocyte count prior and closest to the date of resection as part of the routine preoperative assessment of the patients. Furthermore, in view of the number of patients of this study population and the distribution of the level of PLR with the highest differences before surgery, PLR was further categorized into tertiles to observe whether any reinforced predictive performance could be quantified while maintaining sufficient statistical power in each category.

The written informed consent was obtained from each patient included in the study. The study was approved by the Committee on Ethics at the First Affiliated Hospital of Wenzhou Medical University and was performed according to Standards for the Reporting of Diagnostic Accuracy Studies. A study flow diagram is provided in Fig. 1.

Study flow diagram.
Fig. 1.  Study flow diagram.

Abbreviations: HCC, hepatocellular carcinoma; PEI, percutaneous ethanol injection; RF, radiofrequency; TACE, transarterial chemoembolization.

Exclusion criteria

All cases of suspected HCC were confirmed by post-operative pathology assessment, and the following exclusion criteria were used: (1) previous hepatic resections; (2) distant tumor metastasis; (3) multiple primary tumors; (4) previous primary cancer; (5) previous transcatheter arterial chemoembolization or radiofrequency treatment, percutaneous ethanol injection, liver transplantation, or targeted therapies; (6) non-HCC disease on the basis of post-operative pathological diagnosis; (7) postoperative survival time of ≤ 6 months; (8) loss during follow-up. In total, 481 HCC patients were identified for this study.

Data collection and follow-up

Standard patient demographic and clinic pathological data were collected from the patients’ medical records, including age, BMI, sex, calculated Child-Turcotte-Pugh (CTP) score and the Cancer of the Liver Italian Program (CLIP) score at initial presentation. Laboratory values, including platelet, total bilirubin, direct bilirubin, albumin, alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, blood glucose, creatinine, thrombin time, and international normalized ratio, were recorded for all patients before curative liver resection. Clinical values, including liver cirrhosis (LC) and ascites, were recorded for all patients after assessment by physical examination and confirmation by imaging studies such as abdominal ultrasonography, computerized tomography (CT) or magnetic resonance imaging (MRI). The presence of microvascular invasion was defined by evidence of tumor emboli in either the large capsular vessels, or the portal or central hepatic vein based on imaging studies or surgical resection.27 Tumor characteristics, including portal vein thrombosis, were observed during the surgery, and the number of tumor nodules were ascertained based on CT or MRI scan.

Patients were followed-up every 3 months after surgery and OS was based on the time interval between the date of surgery and death, or the date of surgery and the last follow-up. Information on death was collected from the medical records and the social security death index, as well as from families.

Statistical analysis

Data for continuous variables were expressed in mean ± standard deviation or medians and interquartile range, depending on their distribution in the study population tested by Kolmogorov-Smirnov test. Categorical values were presented as relative frequencies and proportions. Comparisons between stratification were performed using the nonparametric Kruskal-Wallis test or one-way analysis of variance (ANOVA) for continuous variables, and the Pearson’s chi-square test or Fisher’s exact test for categorical variables as appropriate. A Cox proportional hazard regression was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs) associated with OS. Prognostic factors with significant values of p < 0.05 in a univariate analysis were entered into a multivariate analysis, enabling determination of significant effects while adjusting for multiple factors simultaneously. Then, the Kaplan–Meier curves were used for OS rates to compare patients with each stratification, and statistical difference in the survival curves were evaluated using the log-rank test.

In this study, a two-tailed p value of < 0.05 was recognized as statistically significant. All these statistical calculations were performed using SPSS version 18.0 (SPSS, Chicago, IL, USA) and MedCalc version 12.7 (MedCalc Software, Ostend, Belgium).


The 481 patients who underwent CLR for suspected HCC at the First Affiliated Hospital of Wenzhou Medical University between January 2007 and January 2014 consisted of 411 males (85.4%) and 70 females (14.6%). Their mean age was 56.4 years (range, 23–85 years; Table 1).

Table 1.

Characteristics of patients with hepatocellular carcinoma treated by surgical resection according to PLR tertiles

VariablesAll patientsPLR tertiles
Tertile 1, n = 160 [11.98–75.00]Tertile 2, n = 160 [75.00–113.33]Tertile 3, n = 161 [113.33–567.50]p-value
 PLR91.2 (69.0, 129.2)60.0 (48.4, 69.0)91.2 (82.5, 102.2)155.7 (128.9, 192.5)<0.001
Demographic parameters
 Age in years56.4 ± 10.955.6 ± 9.756.8 ± 10.856.8 ± 12.20.507
  Male411 (85.4%)135 (84.4%)142 (88.8%)134 (83.2%)
  Female70 (14.6%)25 (15.6%)18 (11.3%)27 (16.8%)
 BMI in kg/m223.0 ± 3.323.1 ± 3.223.6 ± 3.922.3 ± 2.70.004
Clinical parameters, n (%)
  Absence366 (90.1%)123 (90.4%)129 (92.8%)114 (87.0%)
  Presence40 (9.9%)13 (9.6%)10 (7.2%)17 (13.0%)
 Liver cirrhosis176 (42.6%)81 (58.7%)59 (41.8%)36 (26.9%)<0.001
Etiology, n (%)0.002
 Hepatitis B325 (68.4%)113 (72.9%)109 (68.1%)103 (64.4%)
 Alcohol36 (7.6%)8 (5.2%)9 (5.6%)19 (11.9%)
 Hepatitis B + hepatitis C77 (16.2%)31 (20.0%)28 (17.5%)18 (11.3%)
 Other34 (7.2%)3 (1.9%)13 (8.1%)18 (11.3%)
 Hepatitis C3 (0.6%)01 (0.6%)2 (1.3%)
Laboratory parameters
 Total bilirubin in μmol/L10.0 (8.0, 15.0)12.0 (9.0, 18.0)10.0 (8.0, 15.0)10.0 (8.0, 14.0)0.003
 Direct bilirubin in μmol/L3.5 (2.0, 6.0)4.0 (3.0, 6.0)3.0 (2.0, 5.0)4.0 (3.0, 6.0)0.223
 Albumin in g/L40.7 (37.3, 43.7)39.8 (36.3, 43.3)41.3 (38.3, 43.9)40.7 (37.6, 43.9)0.063
 ALT in IU/L36.0 (25.0, 55.0)38.0 (27.0, 53.0)36.0 (24.3, 54.0)34.0 (21.0, 55.0)0.168
 AST in IU/L37.0 (27.0, 53.0)39.0 (31.0, 54.0)34.0 (26.3, 48.0)37.0 (25.0, 59.0)0.111
 Alkaline phosphatase in IU/L94.0 (75.0, 115.0)96.0 (78.3, 113)89.0 (74.0, 112.0)97.0 (73.0, 121.0)0.283
 γ-GT in IU/L54.0 (33.0, 106.0)53.5 (31.3, 117.0)53.0 (35.0, 90.0)62.0 (33.5, 127.5)0.413
 Blood glucose in mmol/L5.9 (5.0, 7.3)5.7 (4.8, 7.2)6.0 (5.1, 7.1)6.1 (5.1, 7.5)0.371
 Creatinine in μmol/L67.0 (56.3, 76.0)67.0 (58.0, 78.0)68.0 (57.0, 76.8)66.0 (55.0, 75.0)0.434
 Serum sodium in mmol/L141.0 (139.0, 142.0)140.0 (139.0, 142.0)141.0 (139.0, 143.0)141.0 (138.0, 142.5)0.355
 PT in s13.9 (13.3, 14.7)14.4 (13.6, 15.2)13.7 (13.2, 14.4)13.7 (13.1, 14.3)<0.001
 PTA in %88.2 ± 13.783.4 ± 14.289.7 ± 11.991.3 ± 13.6<0.001
 INR1.1 (1.0, 1.2)1.1 (1.1, 1.2)1.1 (1.0, 1.1)1.1 (1.0, 1.1)<0.001
 White blood cell in 109/L5.3 (4.2, 6.7)4.9 (3.6, 6.1)5.7 (4.4, 6.8)5.2 (4.3, 7.0)0.002
 AFP in ng/mL30.7 (5.4, 447.9)34.4 (6.2, 343.1)36.9 (5.3, 430.7)23.2 (5.0, 596.3)0.984
 Uric acid in μmol/L299.4 ± 88.6313.0 ± 91.2296.4 ± 80.0289.0 ± 92.80.047
 Platelet in 109/L138.6 ± 63.596 ± 42.8138.2 ± 47.1181.3 ± 66.4<0.001
Tumor characteristics
 Number of nodules, n (%)0.682
  1403 (87.6%)134 (83.8%)133 (85.3%)136 (88.3%)
  239 (8.5%)12 (7.5%)16 (10.3%)11 (7.1%)
  38 (1.7%)3 (1.9%)3 (1.9%)2 (1.3%)
  ≥410 (2.2%)1 (0.6%)4 (2.6%)5 (3.2%)
 Greatest tumor diameter in mm40.0 (30.0, 60.0)30.0 (20.0, 50.0)40.0 (30.0, 57.5)50.0 (30.0, 80.0)<0.001
 Portal vein thrombosis, n (%)12 (3.0%)2 (1.5%)2 (1.4%)8 (6.1%)0.054
 Microvascular invasion, n (%)121 (25.4%)42 (26.4%)41 (25.9%)38 (23.8%)0.843
CLIP score, n (%)<0.001
 0177 (45.3%)67 (51.1%)60 (44.1%)50 (40.3%)
 185 (21.7%)34 (26%)37 (27.2%)14 (11.3%)
 272 (18.4%)21 (16%)24 (17.6%)27 (21.8%)
 342 (10.7%)7 (5.3%)11 (8.1%)24 (19.4%)
 414 (3.6%)2 (1.5%)4 (2.9%)8 (6.5%)
 51 (0.3%)001 (0.8%)
CTP score, n (%)0.455
 A338 (83.9%)107 (79.9%)120 (87%)111 (84.7%)
 B57 (14.1%)23 (17.2%)17 (12.3%)17 (13.0%)
 C8 (2.0%)4 (3.0%)1 (0.7%)3 (2.3%)
Follow-up data
 Death within 36 months of resection0.003
  Alive145 (61.2%)60 (71.4%)51 (64.6%)34 (45.9%)
  Deceased92 (38.8%)24 (28.6%)28 (35.4%)40 (54.1%)

Based on distribution of the level of PLR, all of the patients were categorized into equal tertiles, which ensured the most categories with adequate number of patients per category from the range of 11.98 to 567.50 (T1, 160 patients; T2, 160 patients; T3, 160 patients). The cut-off values for this stratification of the PLR into tertiles were: (T1) 11.98–75.00, (T2) 75.00–113.33, (T3) 113.33–567.50.

The demographic and tumor, laboratory and clinical characteristics of the HCC patients involved in this study with PLR tertiles are summarized in Table 1. Patients with low and high PLR seemed to be similar in regard to laboratory characteristics, except for white blood cells, uric acid platelets, total bilirubin, prothrombin time (PT), prothrombin time activity and INR. The etiology for most of the cases was hepatitis B virus (HBV) (68.4%), followed by superinfection with HBV and hepatitis C virus (16.2%). The majority of patients had a single tumor (87.6%), and higher PLR tertiles were significantly associated with larger tumor diameter when compared with the lower two tertiles (p < 0.001).

Univariate and multivariate analyses by a Cox proportional hazard model were performed to identify independent prognostic factors for OS, as illustrated in Table 2. The univariate Cox proportional hazards analysis demonstrated that PLR, ascites, PT, albumin, AST, alkaline phosphatase, white blood cells, largest tumor diameter, number of nodules, microvascular invasion, portal vein thrombosis, CLIP score and CTP score (all p < 0.05) were statistically significant prognostic factors for OS.

Table 2.

Univariate and multivariate cox proportional hazards regression analyses of factors associated with mortality

VariablesUnivariate analysisMultivariate analysis
Demographic parameters
 Age in years0.0071.0070.991–1.0240.399
Clinical parameters
 Liver cirrhosis0.2161.2410.834–1.8450.287
Laboratory parameters
 Total bilirubin in μmol/L0.0041.0040.998–1.0100.152
 Direct bilirubin in μmol/L0.0061.0060.998–1.0130.135
 Albumin in g/L−0.0610.9410.913–0.969<0.001
 ALT in IU/L0.0021.0021.000–1.0040.056
 AST in IU/L0.0011.0011.000–1.0020.019
 Alkaline phosphatase in IU/L0.0021.0021.000–1.0030.030
 γ-GT in IU/L0.0011.0011.000–1.0020.067
 Blood glucose in mmol/L0.0331.0330.983–1.0860.198
 Creatinine in μmol/L−0.0040.9960.987–1.0060.470
 Uric acid in μmol/L−0.0010.9990.997–1.0020.635
 Serum sodium in mmol/L0.0041.0040.999–1.0090.160
 PT in s0.1491.1601.021–1.3190.022
 PTA in %−0.0120.9880.975–1.0010.071
 White blood cell in 109/L0.0271.0271.01–1.0440.002
 Platelet in 109/L0.0021.0020.999–1.0040.309
 AFP in ng/mL0.0001.0001.000–1.0000.244
Tumor characteristics
 Number of nodules0.4351.5451.202–1.9870.0010.5941.8101.345–2.437<0.001
 Greatest tumor diameter in mm0.0071.0071.001–1.0120.015
 Portal vein thrombosis1.8806.5542.619–16.401<0.0011.2263.4061.185–9.7940.023
 Microvascular invasion0.9212.5121.749–3.606<0.0011.0042.7301.777–4.196<0.001
CLIP score0.4231.5271.290–1.809<0.001
CTP score0.6861.9861.346–2.9320.0010.5541.7411.129–2.6840.012

After extensive univariate analysis, these significant factors were included in the multivariable Cox proportional hazards models, and multivariable analysis identified that the level of PLR (HR = 1.004, 95%CI: 1.001–1.008, p = 0.006), number of nodules (HR = 1.810, 95%CI: 1.345–2.437, p < 0.001), presence of microvascular invasion (HR = 2.730, 95%CI: 1.777–4.196, p < 0.001), presence of portal vein thrombosis (HR = 3.406, 95%CI: 1.185–9.794, p = 0.023) and CTP score (HR = 1.741, 95%CI: 1.129–2.684, p = 0.012) were independent prognostic factors for OS.

Furthermore, the Kaplan-Meier survival curves of the HCC patients stratified by PLR tertiles demonstrated a higher 5-year OS following CLR (58%) of the lowest PLR tertiles (T1) in comparison to poor outcomes (30%) in the highest tertiles (T3), and each of the tertiles demonstrated a similar difference of OS (log-rank p = 0.016) (Fig. 2).

Overall survival rate of patients who had received curative liver resection, stratified by tertile of PLR.
Fig. 2.  Overall survival rate of patients who had received curative liver resection, stratified by tertile of PLR.

The log-rank p-value among all three tertiles was 0.016. (T1) 11.98–75.00, (T2) 75.00–113.33 and (T3) 113.33–567.50. Patients with the lowest tertile of PLR (T1) had favorable 5-year survival following surgery (58%); however, those in the tertile of PLR (T3) had poor outcomes (30%).


Postoperative recurrence of HCC is a major barrier for long-term survival for HCC patients after liver resection.28 Hence, in this study, we established as first the stratification of preoperative PLR levels for the prediction of 36-month survival in patients with HCC after CLR. Based on Kaplan-Meier analysis of OS, the elevated level of PLR was demonstrated to be associated with the poor survival of HCC and high tertiles of PLR were related to poor prognosis.

More than a century ago, the association of cancer and inflammation was demonstrated.29 However, the mechanism by which the immune response may be triggered via a tumor is complex,30 and numerous research projects focused on underlying mechanism that associates disease prognosis and tumor inflammation have been undertaken.17,31 Recently, accumulative evidence have demonstrated that increased systemic inflammation is associated with poor prognosis in various kinds of cancers, including pancreatic cancer and ovarian cancer.32 Biomarkers of systemic inflammation such as PLR, elevated NLR, and absolute monocyte counts have a potential role in guiding the clinical management of cancer patients, across a range of malignancies.19 PLR is a basic marker of systemic inflammation and can be easily obtained from routine blood cell testing.23 Previous studies have confirmed that a high preoperative PLR was associated with poor prognosis in patients with non-metastatic non-small cell lung cancer,33 resectable small cell carcinoma of the esophagus and HCC.24,34 Additionally, the level of PLR is a widely accepted independent predictor for OS in patients with advanced HCC.24 We stratified PLR as first to predict prognosis in HCC patients after CLR. We also analyzed whether this could be useful to predict a better performance. We found that the presence of elevated pre-operative PLR was associated with poor survival, which is consistent with the systematic review and clinical trial which reported that a high PLR is associated with worse OS in various solid tumors including HCC.35,36

The elevated peripheral blood platelet counts might reflect the tumor-induced systemic inflammatory response.37 Platelet aggregation and degranulation, along with the consequent release of platelet-derived growth factor, platelet-derived proangiogenic mediators, vascular endothelial growth factor and angiopoetin-1, have been verified as important determinants of tumor growth and probably angiogenesis.3840 Previous studies have confirmed that activated platelets impel tumor cell escape from immune elimination by promoting their arrest in the endothelium, thereby causing the secondary lesions.24,41,42 Platelets may also promote the growth and spread of malignancies through non-inflammatory mechanisms, including stimulation of metalloproteinase-9 synthesis, and production of adhesion molecules and growth factors (such as EGF, VEGF, TGFb and PDGF).4345 Carr et al.’s46 study suggested that platelets could also stimulate the growth and invasion of several HCC cell lines in vitro. These studies indicate that platelets may lead to accelerated tumor metastasis and progression in cancers. Therefore, the underlying mechanisms of the interactions of platelet-tumor cells need to be studied more extensively, for the purpose of providing more appropriate treatment plans for individual patients in high-risk situations for HCC.

In recent years, some studies in oncology have explored whether a better effect on disease prognosis can be achieved by stratifying the independent predictor. For instance, Blank et al.47 categorized AFP into quintiles and created the opportunity to observe differences in outcomes among HBV-HCC patients after surgical resection. And, another study categorized patients into equal tertiles according to their baseline of NLR and PLR, demonstrating that an elevated pretreatment NLR is an independent predictor of both worse overall and disease-free survival in colorectal cancer.48 In this study, based on the fact that PLR is a widely accepted HCC risk factor, we categorized PLR into equal tertiles to investigate whether any enhanced predictive effect was detected. Consequently, we gained greater confidence in being able to predict clinical outcome. The Kaplan–Meier curve analyses revealed that patients with the highest tertile of PLR (a 5-year survival of 30%) had significantly shorter OS compared to those with the lowest tertile of PLR (a 5-year survival of 58%). These new categories have shown significant and distinct survival outcomes in HCC patients after CLR. We believe it may be helpful in guiding the clinician to predict the prognosis of cancer and in selecting the most appropriate treatment or palliative care to improve survival rate. Hence, our study suggests that the stratification of PLR could independently and reliably predict the disease prognosis for suspected HCC patients after CLR.

This study has several limitations. First of all, the findings include a relatively homogeneous patient cohort and may not be applicable to HCC patients who received other therapies or surgeries. Moreover, additional large-scale clinical research studies are needed to confirm these findings and to evaluate the effect of categorizing PLR on patients who underwent CLR for suspected HCC. Finally, in view of recurrence after resection being an important prognostic factor, we intend to further record more data in the future.

In summary, this study highlights the potential of PLR as an additional prognostic tool and performs for the first time a categorization of HCC patients with preoperative PLR into tertiles, with significantly improved outcomes among HCC patients following CLR. We suggest that clinicians should consider the level of preoperative PLR as a helpful tool to select the most appropriate therapy scheme for their HCC patients.





aspartate aminotransferase


confidence interval


Cancer of the Liver Italian Program


curative liver resection


computerized tomography


hepatitis B virus


hepatocellular carcinoma


hazard ratio


liver cirrhosis


magnetic resonance imaging


neutrophil-to-lymphocyte ratio


overall survival


platelet-to-lymphocyte ratio


γ-glutamyl transferase



This work was supported by grants from the National Natural Science Foundation of China (No. 81500665), Scientific Research Foundation of Wenzhou (No. Y20160223), High Level Creative Talents from Department of Public Health in Zhejiang Province, and the Project of New Century 551 Talent Nurturing in Wenzhou to MH Zheng. No writing assistance was obtained for this manuscript.

Conflict of interest

The authors have no conflict of interests related to this publication.

Authors’ contributions

These three authors contributed equally to this study.


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