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Online First Articles

The online first articles are peer reviewed, accepted, and are ready for publication, with copyediting, typesetting, proofreading and author review. They have not been assigned to a journal issue; an article will be removed from this page once it is published in a coming issue.

Articles published online first are citable. To cite an article on this page, please refer to the following example:

Yi SG, Sadhu AR, Jones SL, Turner K, Monsour H, Donahue K, et al. The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation. J Clin Transl Hepatol. Published online: Sep 15, 2013. doi: 10.14218/JCTH.2013.00007.

Original Article

Metabolic Liver Diseases

SOX9 Overexpression Ameliorates Metabolic Dysfunction-associated Steatohepatitis Through Activation of the AMPK Pathway

Juan Deng, Kai Ding, Shuqing Liu, Fei Chen, Ru Huang, Bonan Xu, Xin Zhang, Weifen Xie

Published online: December 20, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00197

Infectious Hepatitis

Peripheral Blood CD4⁺/CD8⁺ T Cell Ratio Predicts HBsAg Clearance in Inactive HBsAg Carriers Treated with Peginterferon Alpha

Fengping Wu, Chenrui Liu, Ling He, Yikai Wang, Xin Zhang, Miaoxian Li, Rui Lu, Pei Kang, Mei Li, Yaping Li, Xiaoli Jia, Shuangsuo Dang

Published online: December 6, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00240

Liver Failure, Cirrhosis and Portal Hypertension

Evaluation of Plasma Neurodegenerative Biomarkers for Diagnosing Minimal Hepatic Encephalopathy and Predicting Overt Hepatic Encephalopathy in Chinese Patients with Hepatic Cirrhosis

Qiuyu Cheng, Yunhui Liu, Zhongyuan Yang, Meng Zhang, Tingting Liu, Yuxin Niu, Wei Liu, Lanyue Huang, Yuzhao Feng, Xiaoyun Zhang, Xiaoping Luo, Qin Ning, Tao Chen

Published online: December 12, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00413

Risk of Coronary Artery Disease in Patients with Liver Cirrhosis: A Systematic Review and Meta-analysis

Chunru Gu, Liyan Dong, Lu Chai, Zhenhua Tong, Fangbo Gao, Walter Ageno,  Fernando Gomes Romeiro, Xingshun Qi

Published online: November 21, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00226

Sodium Butyrate Inhibits Necroptosis by Regulating MLKL via E2F1 in Intestinal Epithelial Cells of Liver Cirrhosis

Yimeng Zhou, Yang Ding, Yanwei Li, Qiuju Sheng, Chao Han, Yaoxin Fan, Ziyi Wang, Bingchao Lu, Xiaoguang Dou, Chong Zhang

Published online: November 8, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00221

Hepatic and Biliary Neoplasia

Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review

Yin-Ping Wu, Xue-Yan Yang, Yu-Xin Tian, Jin Feng, Yee Hui Yeo, Fan-Pu Ji, Ming-Hua Zheng, Yu-Chen Fan

Published online: December 17, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00379

HBx Facilitates Drug Resistance in Hepatocellular Carcinoma via CD133-regulated Self-renewal of Liver Cancer Stem Cells

Xiangshu Jin, Huijun Dong, Juan Wang, Guomin Ou, Xinyuan Lai, Xing Tian, Lei Wang, Hui Zhuang, Tong Li, Kuanhui Xiang

Published online: November 25, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00259

Burden of Liver Cancer Attributable to Hepatitis B and Alcohol Globally, in China, and for Five Sociodemographic Index Regions from 1990 to 2021: A Population-based Study

Xiuxiu Deng, Hui Li, Yuru Zhong, Haibo Wang, Lixin Ke, Zhifei Wang, Alexios-Fotios A. Mentis, Yangqin Xun, Qiang Zhang, Cuncun Lu

Published online: November 11, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00351

Liver Injury, Autoimmune, and Cholestatic Diseases

ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury

Mingyan Ji, Yun Chen, Yifan Ma, Dongping Li, Jin Ren, Hongyue Jiang, Sinuo Chen, Xiaoqing Zeng, Hong Gao

Published online: November 22, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00233

Plasma Extracellular Vesicle-derived MicroRNA Associated with Human Alpha-1 Antitrypsin Deficiency-mediated Liver Disease

Regina Oshins, Zhiguang Huo, Zachary Greenberg, Virginia Clark, Sergio Duarte, Huiping Zhou, Jesse West, Mei He, Mark Brantly, Nazli Khodayari

Published online: November 19, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00253

Review Article

Exosome-mediated Crosstalk in the Tumor Immune Microenvironment: Critical Drivers of Hepatocellular Carcinoma Progression

Yifei Ge, Lixue Jiang, Qingfu Dong, Yi Xu, Judy Wai Ping Yam, Xiangyu Zhong

Published online: November 28, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00302

The Development and Appraisal of MELD 3.0 in Liver Diseases: Good Things Never Come Easy

Gaoyue Guo, Wanting Yang, Jia Li, Ziyi Yang, Jing Liang, Chao Sun

Published online: November 12, 2024

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00303

T-cell Receptor Repertoire Analysis in the Context of Transarterial Chemoembolization Synergy with Systemic Therapy for Hepatocellular Carcinoma

Jie Li, Yuyuan Zhang, Luqi Hu, Heqing Ye, Xingli Yan, Xin Li, Yifan Li, Shuwen Ye, Bailu Wu, Zhen Li