Online First Articles
The online first articles are peer reviewed, accepted, and are ready for publication, with copyediting, typesetting, proofreading and author review. They have not been assigned to a journal issue; an article will be removed from this page once it is published in a coming issue.

Articles published online first are citable. To cite an article on this page, please refer to the following example:

Yi SG, Sadhu AR, Jones SL, Turner K, Monsour H, Donahue K, et al. The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation. J Clin Transl Hepatol. Published online: Sep 15, 2013. doi: 10.14218/JCTH.2013.00007.

Original Article

Metabolic Liver Diseases

Differential Mortality Outcomes in Real-world Patients with Lean, Nonobese, and Obese Nonalcoholic Fatty Liver Disease

Vy H. Nguyen, Audrey Ha, Nicholas Ajit Rouillard, Richard Hieu Le, Ashley Fong, Surya Gudapati, Jung Eun Park, Mayumi Maeda, Scott Barnett, Ramsey Cheung, Mindie H. Nguyen

Published online: November 27, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00016

Infectious Hepatitis

Antiviral Therapy Favors a Lower Risk of Liver Cirrhosis in HBeAg-negative Chronic Hepatitis B with Normal Alanine Transaminase and HBV DNA Positivity

Jing Zhou, Fa-Da Wang, Lan-Qing Li, Yu-Jin Li, Shi-Yan Wang, En-Qiang Chen

Published online: August 25, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00272

DILI, Autoimmune, and Cholestatic Diseases

Predictive Model of Oxaliplatin-induced Liver Injury Based on Artificial Neural Network and Logistic Regression

Rui Huang, Yuanxuan Cai, Yisheng He, Zaoqin Yu, Li Zhao, Tao Wang, Xiaofang Shangguan, Yuhang Zhao, Zherui Chen, Yunzhou Chen, Chengliang Zhang

Published online: December 4, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00399

ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling

Shanshou Liu, Jiangang Xie, Chujun Duan, Xiaojun Zhao, Zhusheng Feng, Zheng Dai, Xu Luo, Yu Li, Minghe Yang, Ran Zhuang, Junjie Li, Wen Yin

Published online: November 13, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00171

Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated 3α,6α,7α,12α-Tetrahydroxylated Bile Acid in Cholestasis

Teng Liu, Ren-Xue Wang, Jun Han, Zhong-Die Li, Jonathan A. Sheps, Li-Juan Zheng, Xiao-Xiao Xu, Victor Ling, Jian-She Wang

Published online: September 15, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00095

Safety and Immunogenicity After Primary and Booster Inactivated SARS-Cov-2 Vaccination in Patients with Autoimmune Liver Diseases

Zhiwei Chen, Yuting Wang, Taiyu He, Hu Li, Ling Ao, Qingbo Pan, Yingzhi Zhou, Qian Zhu, Dejuan Xiang, Gaoli Zhang, Ning Ling, Min Chen, Peng Hu, Mingli Peng, Dachuan Cai, Dazhi Zhang, Hong Ren

Published online: September 6, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00049

Liver Failure, Cirrhosis and Portal Hypertension

Causal Relationship Between Gut Microbiota and Liver Cirrhosis: 16S rRNA Sequencing and Mendelian Randomization Analyses

Mengqin Yuan, Xue Hu, Lichao Yao, Ping Chen, Zheng Wang, Pingji Liu, Zhiyu Xiong, Yingan Jiang, Lanjuan Li

Published online: November 30, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00259

Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis

Yingqian Wang, Yujia Li, Yangling Qiu, Min Shen, Ling Wang, Jiangjuan Shao, Feng Zhang, Xuefen Xu, Zili Zhang, Mei Guo, Shizhong Zheng

Published online: August 25, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00162

Dynamic Humoral Immune Response to Primary and Booster Inactivated SARS-CoV-2 Vaccination in Patients with Cirrhosis

Qian Zhu, Lu Wang, Xiaoxiao Hu, Yingzhi Zhang, Tianquan Huang, Taiyu He, Zhiwei Chen, Gaoli Zhang, Mingli Peng, Min Chen, Dachuan Cai, Xiaofeng Shi, Hong Ren

Published online: August 25, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00108

Hepatic and Biliary Neoplasia

E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular carcinoma Development by Inhibiting Pyroptosis

Cuicui Xiao, Jiao Gong, Yusheng Jie, Weicheng Liang, Yan Tai, Wei Qin, Tongyu Lu, Yutian Chong, Ziqing Hei, Bo Hu, Qi Zhang

Published online: October 30, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00292

Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and Metabolic Reprogramming

Silvia Ribback, Kristin Peters, Mohd Yasser, Jessica Prey, Paula Wilhelmi, Qin Su, Frank Dombrowski, Peter Bannasch

Published online: October 19, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00242

New First-line Immunotherapy-based Therapies for Unresectable Hepatocellular Carcinoma: A Living Network Meta-analysis

Jian-Jian Chen, Zhi-Cheng Jin, Biao Luo, Yu-Qing Wang, Rui Li, Hai-Dong Zhu, Gao-Jun Teng

Published online: September 6, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00188

Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma

Mengzhu Li, Xiude Fan, Jiajun Zhao, Dawei Wang

Published online: July 25, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00019

Liver Transplantation and Surgery

L-GrAFT7 has High Accuracy in Predicting Early Allograft Failure after Liver Transplantation: A Multicenter Cohort Study in China

Songming Li, Qijie Luo, Shirui Chen, Zehua Jia, Tielong Wang, Xinyu Yu, Wenjing Wang, YuyiZhang, Jiaxing Zhu, Feiwen Deng, Qiang Sun, Zhiyong Guo, Xiaoshun He

Published online: August 17, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00178

Review Article

Liver Lesions at Risk of Transformation into Hepatocellular Carcinoma in Cirrhotic Patients: Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement

Nicolò Brandi, Matteo Renzulli

Published online: November 29, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00130

Role of Exosomal Modulation of Macrophages in Liver Fibrosis

Bin Fan, He Xie, Qi Tan, Qingyuan Li, Tao Gong, Baoren He, Yujia Li, Limin Chen

Published online: November 23, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00381

Update on the Diagnosis and Treatment of Combined Hepatocellular Cholangiocarcinoma

Kai-Jian Chu, Yoshikuni Kawaguchi, Han Wang, Xiao-Qing Jiang, Kiyoshi Hasegawa

Published online: November 15, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00189

An Overview of the Role of Peroxisome Proliferator-activated Receptors in Liver Diseases

Zahra Changizi, Forough Kajbaf, Azam Moslehi

Published online: November 15, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00334

Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis

Meihua Sun, Yanqing Zhang, Anbing Guo, Zongting Xia, Lijun Peng

Published online: October 30, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00231

Update on the STING Signaling Pathway in Developing Nonalcoholic Fatty Liver Disease

Wei Liu, Zhili Zhang Chen, Chenhui Yang, Yaofu Fan, Liang Qiao, Shaofeng Xie, Lin Cao

Published online: September 28, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00197

Novel Approaches to Inhibition of HBsAg Expression from cccDNA and Chromosomal Integrants: A Review

Ahmed H. Abdelwahed, Brent D. Heineman, George Y. Wu

Published online: September 19, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00067

Nonalcoholic Fatty Liver Disease and the Intestinal Microbiome: An Inseparable Link

Maria Effenberger, Christoph Grander, Felix Grabherr, Herbert Tilg

Published online: September 15, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00069

Single-cell Technologies Provide Novel Insights into Liver Physiology and Pathology

Guanzi Chen, Wenli Xu, Zhicong Long, Yutian Chong, Bingliang Lin, Yusheng Jie

Published online: September 1, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00224

Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications

Jasmine Tidwell, George Y. Wu

Published online: August 25, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00252

Liquid Liver Biopsy for Disease Diagnosis and Prognosis

Desislava K. Tsoneva, Martin N. Ivanov, Manlio Vinciguerra

Published online: July 27, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00040

Hepatocellular Carcinoma Risk Scores from Modeling to Real Clinical Practice in Areas Highly Endemic for Hepatitis B Infection

Xin Hao, Rong Fan, Hong-Mei Zeng, Jin-Lin Hou

Published online: July 19, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00087

Illuminating and Instructive Clinical Case

Hepatocellular Carcinoma with Gastric Metastasis Mimicking a 4 cm Gastrointestinal Stromal Tumor After a 3-year Disease-free Interval

Wei-Ting Chen, Shiu-Feng Kathy Huang, Ming-Ling Chang, Yun-Fan Liaw

Published online: October 23, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00282

Guideline

Guidelines for the Management of Esophagogastric Variceal Bleeding in Cirrhotic Portal Hypertension

Xiaoyuan Xu, Chengwei Tang, Enqiang Linghu, Huiguo Ding, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Digestive Endoscopy, Chinese Medical Association

Published online: October 17, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00061

Research Letter

Associations Between Active, Passive Smoking and the Risk of Nonalcoholic Fatty Liver Disease

Xinyuan Ge, Jing Lu, Chengxiao Yu, Wen Guo, Ting Tian, Xin Xu, Yuqing Ding, Jiaxin Gao, Wei Zhao, Xiaohua Zhou, Qingqing Diao, Hongxia Ma, Qun Zhang, Ci Song, Hongbing Shen

Published online: September 19, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00165

Consensus

Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma (2022 version)

Han Wang, Jun Chen, Xin Zhang, Xia Sheng, Xiao-Yan Chang, Jie Chen, Min-Shan Chen, Hui Dong, Guang-Jie Duan, He-Ping Hu, Zhi-Yong Huang, Wei-Dong Jia, Xiao-Qing Jiang, Dong Kuang, Shan-Shan Li, Zeng-Shan Li, Chang-Li Lu, Shu-Kui Qin, Xue-Shan Qiu, Li-Juan Qu, Chun-Kui Shao, Feng Shen, Guo-Ming Shi, Su-Sheng Shi, Yu-Jun Shi, Hui-Chuan Sun, Xiao-Dong Teng, Bin Wang, Zhan-Bo Wang, Tian-Fu Wen, Jia-Mei Yang, Qiao-Qiao Yang, Sheng-Long Ye, Hong-Fang Yin, Zhen-Gang Yuan, Jing-Ping Yun, Feng-Lin Zang, Hong-Qi Zhang, Li-Hong Zhang, Jing-Min Zhao, Jian Zhou, Wei-Xun Zhou, Jia Fan, Xiao-Ping Chen, Wan Yee Lau, Yuan Ji, Wen-Ming Cong

Published online: July 24, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2023.00118

Corrigendum

Corrigendum: Osteopontin Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty Liver Disease

Published online: November 13, 2023

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00474C

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