Original Article

Metabolic Liver Diseases

Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota Fulin Nian, Longyun Wu, Qiaoyun Xia, Peiying Tian, Chunmei Ding, Xiaolan Lu Published online: February 22, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00415

Comparison of Clinical Characteristics and Outcomes of MAFLD and NAFLD in Chinese Health Examination Populations Xin Xu, Xiaohua Zhou, Ting Tian, Yuqing Ding, Chengxiao Yu, Wei Zhao, Xiao Wang, Jing Lu, Wen Guo, Longfeng Jiang, Quanrongzi Wang, Qun Zhang, Ci Song Published online: January 12, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00154

Infectious Hepatitis

Immunomodulatory and Antiviral Therapy Improved Functional Cure Rate in CHB Patients with High HBsAg Level Experienced NA Hongyu Jia, Guodong Yu, Jiong Yu, Xiaoli Zhang, Lisha Yang, Bin Wang, Jiming Zhang, Lang Bai, Xinxin Zhang, Kai Wang, Ping Zhao, Dongliang Yang, Yingren Zhao, Yanyan Yu, Yimin Zhang, Jueqing Gu, Chanyuan Ye, Huan Cai, Yingfeng Lu, Dairong Xiang, Liang Yu, Jiangshan Lian, Jianhua Hu, Shanyan Zhang, Ciliang Jin, Yida Yang Published online: March 10, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00413

Vaginal Delivery and Breastfeeding Benefit Infant Immune Response to Hepatitis B Vaccine: A Prospective Cohort Study Huiqing Liu, Lili Li, Yali Li, Minmin Liu, Yarong Song, Feng Ding, Xiaoshu Zhang, Jie Li Published online: March 7, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00032S

IL2-inducible T-cell Kinase is Required for HBV-induced Type T Interferon Expression and Antiviral Response Mengxin Lin, Ruyi Guo, Dawu Zeng, Jiangfu Liu, Minghui Zheng, Zhijun Su Published online: February 7, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00299

Liver Stiffness Measurement can Predict Liver Inflammation in Chronic Hepatitis B Patients with Normal Alanine Transaminase Ling-Ling Huang, Xue-Ping Yu, Qing-Fa Ruan, Yan-Xue Lin, Huan Li, Wen Jin, Rui-Feng Liu, Yan-Lan Liang, Yu-Rui Liu, Yue-Yong Zhu, Jia-Ji Jiang, Ri-Cheng Mao, Da-Wu Zeng Published online: January 18, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00329

Double Plasma Molecular Adsorption System with Sequential Low-dose Plasma Exchange in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure: A Prospective Study Lu Wang, Wenxiong Xu, Shu Zhu, Guoli Lin, Jing Lai, Yufeng Zhang, Ying Liu, Lihua Zheng, Qiumin Luo, Zhiliang Gao, Chan Xie, Liang Peng Published online: January 9, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00254

DILI, Autoimmune, and Cholestatic Diseases

IL-33 Downregulates Hepatic Carboxylesterase 1 in Acute Liver Injury via Macrophage-Derived Exosomal miR-27b-3p Ping Gao, Min Li, Jingli Lu, Daochun Xiang, Ximin Wang, Yanjiao Xu, Yue Zu, Xinlei Guan, Guodong Li, Chengliang Zhang Published online: March 16, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00144

Liver Failure, Cirrhosis and Portal Hypertension

Performance of the Enhanced Liver Fibrosis Score, Comparison with Vibration-controlled Transient Elastography Data, and Development of a Simple Algorithm to Predict Significant Liver Fibrosis in a Community-based Liver Service: A Retrospective Evaluation Tina Reinson, Janisha Patel, Mead Mathews, Derek Fountain, Ryan M. Buchanan, Christopher D. Byrne Published online: February 24, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00335

IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis Lichao Yao, Xue Hu, Mengqin Yuan, Qiuling Zhang, Pingji Liu, Lian Yang, Kai Dai, Yingan Jiang Published online: January 31, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00392

Portal Fibrotic Cord is Associated with Transjugular Intrahepatic Portosystemic Shunt Failure and Death in Cirrhotic Patients Yunshu Yang, Chuangye He, Xulong Yuan, Kai Li, Wenyuan Jia, Jing Niu, Na Han, Jiao Xu, Ying Zhu, Li Xu, Yuxuan Mao, Yuanping Xu, Xiaoyuan Gou, Jun Tie Published online: January 4, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00391

Hepatic and Biliary Neoplasia

Exosome-transported circHDAC1_004 Promotes Proliferation, Migration, and Angiogenesis of Hepatocellular Carcinoma by the miR-361-3p/NACC1 Axis Bin Xu, Wenbo Jia, Yanzhi Feng, Jinyi Wang, Jing Wang, Deming Zhu, Chao Xu, Litao Liang, Wenzhou Ding, Yongping Zhou, Lianbao Kong Published online: March 22, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00097

Single-cell RNA-seq Revealed that Altered Tumor Infiltrating Lymphocytes in Cirrhotic Liver Indicate Development of Hepatocellular Carcinoma Jingxian Duan, Peng Zhu, Yong Zhang, Tianhao Mu, Yingqiang Li, Rui Xiong, Su Chen, Yingmei Li, Zhicheng Li, Shifu Chen, Lei Zhang Published online: March 16, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00062

Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma Zhitao Jiang, Liyuan Gao, Chundi Liu, Jianchun Wang, Yi Han, Jinhuo Pan Published online: January 31, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00312

Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma Chao-Xu Fu, Jun Li, Zheng-Da Chen, Yan-Ping Cao, Hong-Ling Zhang, Hong-Ting Sui, Bao-Cheng Shan, Lei Xu, Yang Zhou, Min Zhou, En-Yue Yang, Hong-Xin Piao Published online: January 28, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00285

Aminoacyl-tRNA Synthetase-based Prognosis Model and Exploration of Potential Mechanisms in Hepatocellular Carcinoma Yixun Jin, Xinyang Huang, Zhuoxin Wang, Hui Xu, Qi Wang, Lifu Wang Published online: January 17, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00301

Liver Transplantation and Surgery

Randomized Trial of Ciclosporin with 2-h Monitoring vs. Tacrolimus with Trough Monitoring in Liver Transplantation: DELTA Study Bastian N. Ruijter, Akin Inderson, Aad P. van den Berg, Herold J. Metselaar, Jeroen Dubbeld, Maarten E. Tushuizen, Robert J. Porte, Wojciech Polak, Danny van der Helm, Marjolein van Reeven, Mar Rodriguez-Girondo, Bart van Hoek Published online: March 7, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00348

Stratified Analysis of Survival Benefit for ABO-incompatible Deceased-donor Liver Transplantation: Multicenter Propensity Score-matched Study Mengfan Yang, Xuyong Wei, Abdul Rehman Khan, Qiang Wei, Rui Wang, Binhua Pan, Kun Wang, Zhisheng Zhou, Di Lu, Beini Cen, Shuijun Zhang, Wenzhi Guo, Shusen Zheng, Yang Yang, Xiao Xu Published online: February 1, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00297

Review Article

Emerging Therapeutic Strategies in the Fight Against Primary Biliary Cholangitis Abigail Medford, Jonathan Childs, Ashleigh Little, Sanjukta Chakraborty, Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser Published online: March 16, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00398

Strategies to Prevent Mother-to-child Transmission of Hepatitis B Virus Palittiya Sintusek, Nasamon Wanlapakorn, Yong Poovorawan Published online: March 10, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00332

Primary Non-HFE Hemochromatosis: A Review Alla Turshudzhyan, David C. Wu, George Y. Wu Published online: February 2, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00373

Cardiac Syndromes in Liver Disease: A Clinical Conundrum Milos Brankovic, Paul Lee, Nikolaos Pyrsopoulos, Mark Klapholz Published online: February 1, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00294

Secondary Iron Overload and the Liver: A Comprehensive Review Kanokwan Pinyopornpanish, Adisak Tantiworawit, Apinya Leerapun, Atiwat Soontornpun, Satawat Thongsawat Published online: February 1, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00420

Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside Li Zhang, Ling Yang, Huikuan Chu Published online: March 1, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00408

Primary Hepatic Extra-gastrointestinal Stromal Tumors: Molecular Pathogenesis, Immunohistopathology, and Treatment Erica C. Becker, Gonca Ozcan, George Y. Wu Published online: January 30, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00173

Hot Topic Commentary

R0 Liver Resection should be a First-line Treatment for Selected Patients with Intermediate Hepatocellular Cancer Martin Janicko, Sylvia Drazilova, Peter Jarcuska Published online: March 17, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00123

Illuminating and Instructive Clinical Case

Portal Hypertension Refractory Ascites Caused by Secondary Hemochromatosis Jun Tie, Wen Yuan Jia, Xiaoyuan Gou Published online: March 7, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00418

Synchronous Double Primary Combined Hepatocellular-cholangiocarcinoma and Cholangiolocarcinoma in a Cirrhotic Liver Masahiro Sakata, Koji Kitada, Rika Omote, Hiroshi Sonobe, Masashi Utsumi, Naoyuki Tokunaga, Takashi Fushimi, Ryota Nagao, Tatsuro Sakata, Toshihiko Kaneyoshi, Tatsuya Toyokawa, Masaru Inagaki Published online: February 8, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00382

Research Letter

TDF Promotes Glycolysis and Mitochondrial Dysfunction to Accelerate Lactate Accumulation by Downregulating PGC1α in Mice Yuxuan Luo, Zhiwei Chen, Zhao Li, Aoran Luo, Yi Zeng, Min Chen, Mingli Peng, Hong Ren, Peng Hu Published online: February 3, 2023 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00082