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Online First Articles

The online first articles are peer reviewed, accepted, and are ready for publication, with copyediting, typesetting, proofreading and author review. They have not been assigned to a journal issue; an article will be removed from this page once it is published in a coming issue.

Articles published online first are citable. To cite an article on this page, please refer to the following example:

Yi SG, Sadhu AR, Jones SL, Turner K, Monsour H, Donahue K, et al. The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation. J Clin Transl Hepatol. Published online: Sep 15, 2013. doi: 10.14218/JCTH.2013.00007.

Original Article

Metabolic Liver Diseases

Investigation of HO-1 Regulation of Liver Fibrosis Related to Nonalcoholic Fatty Liver Disease Through the SIRT1/TGF-ß/Smad3 Pathway

Mengjiao Sun, Xiaoqing Wu, Zhandong Lin, Congyue Zhang, Jiawei Cui, Yaoyao Mao, Yue Shi, Jiaming Zhang, Yuemin Nan

Published online: March 12, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00481

Intestinal Depletion of TM6SF2 Exacerbates High-fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis

Li-Zhen Chen, Yu-Rong Wang, Zhen-Zhen Zhao, Shou-Lin Zhao, Cong-Cong Min, Yong-Ning Xin

Published online: March 12, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00407

Ursolic Acid Modulates Estrogen Conversion to Relieve Inflammation in Metabolic Dysfunction-associated Steatotic Liver Disease via HSD17B14

Simin Gu, Hui Zhang, Zhekun Xiong, Chong Chen, Junmin Wang, Dan Fang, Yiyuan Zheng, Yong Li

Published online: March 10, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00414

Infectious Hepatitis

Hydronidone for the Treatment of Liver Fibrosis Associated with Chronic Hepatitis B: Protocol for a Phase 3 Randomized Trial

Xiaobo Cai, Yin Qu, Wen Xie, Yanbin Wang, Mengyu Zhao, Ling Zhang, Ying Luo, Ping Yin, Jun Cheng, Lungen Lu

Published online: March 10, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00472

Prevalence of Hepatitis D Virus Antibody Positivity in Chinese Patients with Chronic Hepatitis B Virus Infection

Xieer Liang, Qiaoqiao Chen, Hong Tang, Yujuan Guan, Minfeng Liang, Peng Hu, Wen Xie, Huiying Rao, Junqi Niu, Liang Chen, Li Yan, Xiaowei Chen, Xiaohe Li, Yulin Zhao, Oliver Lenz, Michael Biermer, Jinlin Hou

Published online: February 24, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00313

Liver Failure, Cirrhosis and Portal Hypertension

Improved Discrimination and Predictive Ability of Novel Prognostic Scores for Long-term Mortality in Hospitalized Patients with Cirrhosis

Sipu Wang, Gaoyue Guo, Han Wang, Xuqian Zhang, Wanting Yang, Jie Yang, Liping Wu, Chao Sun

Published online: March 11, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00004

Mitochondrial Membrane Potential of CD8⁺ T Cells Predicts Bacterial Infection and Rapid Development of Acute-on-chronic Liver Failure in Cirrhotic Patients

Xixuan Wang, Shuling Chen, Jing Fan, Yuxiang Gong, Hongli Liu, Lili Wang, Xiaoning Feng, Hui Zhou, Wenquan Zeng, Changhua Yi, Caiyun Zhang, Qingfang Xiong, Hao Ren, Yongfeng Yang

Published online: February 25, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00452

Clinical Characteristics, Treatment Effects and Risk Factors of Liver Cirrhosis in Patients with Wilson’s Disease Hepatic Type

Yu-Jia Lu, Chuan-Su Yuan, Yue-Yang Ma, Ke-Ying Ou, Du-Xian Liu, Bin Liu, Yong-Feng Yang, Qing-Fang Xiong

Published online: February 19, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00453

Hepatic and Biliary Neoplasia

GTF3C2 Promotes the Proliferation of Hepatocellular Carcinoma Cells through the USP21/MEK2/ERK1/2 Pathway

Yani Wu, Yingnan Yang, Youju Zhang, Qiuran Xu, Dongsheng Huang, Kangsheng Tu

Published online: February 11, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00386

Liver Transplantation and Surgery

The Impact of Liver Graft Preservation Method on Longitudinal Gut Microbiome Changes Following Liver Transplant: A Proof-of-concept Study

Gail A.M. Cresci, Qiang Liu, Naseer Sangwan, Darren Liu, David Grove, David Shapiro, Khaled Ali, Beatrice Cazzaniga, Luca Del Prete, Charles Miller, Koji Hashimoto, Cristiano Quintini

Published online: January 22, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00352

Liver Injury, Autoimmune, and Cholestatic Diseases

Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury

Zhu Yang, Yang Tai, Tian Lan, Chong Zhao, Jin-Hang Gao, Cheng-Wei Tang, Huan Tong

Published online: March 3, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00440

PCSK9 and APOA4: The Dynamic Duo in TMAO-induced Cholesterol Metabolism and Cholelithiasis

Chao Shi, Jingjing Yu, Ziang Meng, Dongxu Lu, Haoran Ding, Haijun Sun, Guangxin Shi, Dongbo Xue, Xianzhi Meng

Published online: February 11, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00403

Review Article

Non-variceal Extrahepatic Portosystemic Shunts: A Review of Pathogenesis, Diagnosis, and Treatment

Nicole M. Anastasio, George Y. Wu

Published online: March 14, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00315

Hepatocellular Carcinoma and the Role of Liver Transplantation: An Update and Review

Lynette M. Sequeira, N. Begum Ozturk, Leandro Sierra, Merve Gurakar, Merih Deniz Toruner, Melanie Zheng, Cem Simsek, Ahmet Gurakar, Amy K. Kim