Original Article

Infectious Hepatitis

High Frequency of Circulating IL-4R+SELL+ Naïve B Cells Is Associated with Functional Cure in Chronic Hepatitis B Patients Receiving Antiviral Treatment Lili Tang, Chunmei Bao, Cheng Zhen, Huan Wang, Chao Zhang, Yang Zhang, Honghong Liu, Jinwen Song, Yanmei Jiao, Tao Yang, Yue Yuan, Jinhong Yuan, Yingying Gao, Yangliu Chen, Lin Cao, Jing Li, Jun-Liang Fu, Fu-Sheng Wang, Ruonan Xu Published online: August 26, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00356

Mass Cytometry Reveals Cell Type-specific Immune Remodeling in Placentas of Women with Chronic Hepatitis B Infection Zirong Yang, Li Qi, Yang Bai, Weiwei Zhou, Wenjing Wang, Yunxia Zhu, Junfeng Lu Published online: August 26, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00429

Comparison of Peg-INF plus TDF versus TDF Monotherapy in Indeterminate-phase Chronic Hepatitis B Patients with High HBsAg levels, HBeAg-negative status, and Normal ALT Levels Min Liu, An Xiao, Bing Bu, Lili Zuo, Yuting Zhang, Ling Zhu, Liping Huang, Yilan Wang, Jinbo Luo, Wei Yue, Jiawei Geng Published online: August 4, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00015

Hepatic and Biliary Neoplasia

Palmatine Induces TNNT1 Ubiquitination and Degradation to Potentiate Ferroptosis Sensitivity in Hepatocellular Carcinoma Xiaokang Wang, Fanci Xie, Chunhua Wang, Shangjun Zhou, Jiayu Wang, Zhijie Xu, Zhiyang Zhou Published online: August 19, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00215

Lipid Metabolism-related lncRNA Model Identifies AC026412.3 as a Driver of Fatty Acid β-oxidation in Hepatocellular Carcinoma Lixin Liu, Yuhao Fan, Hao Zou, Sheng Hu, Kui Long, Lianghua Li, Chaosheng Xia, Hongyue Wang, Yang Liu, Runlin Feng, Zongqi Deng, Qiang Kang Published online: August 13, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00312

Metabolic Liver Diseases

Integrative Multi-omics and Machine Learning Reveal the Therapeutic Mechanisms of Juanyu-Xiaozhi Formula in Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatic Fibrosis via the AP-1/PPARγ/SCD1 Axis Zhiqiang Jin, Yi Huang, Cheng Zeng, Yueting Zhang, Yu Qiu, Yang Yang, Huabao Liu Published online: August 7, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00106

Comparative Efficacy of Promising Targets in the Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Network Meta-analysis Wenjing Ni, Jie Li, Xue Bai, Sisi Zhou, Xiangyu Wu, Leyao Jia, Zhuoru Jiang, Jiali Wu, Ming Li, Connie Wong, Chao Wu, Junping Shi, Mindie H. Nguyen Published online: July 20, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00596

Liver Injury, Autoimmune, and Cholestatic Diseases

Early Prediction of Non-recovery in Drug-induced Liver Injury by Integrating Genetic Variants and Clinical Variables: An Interpretable Machine Learning Approach Jingjing Jiang, Weiwei Lou, Qing Li, Ziqiang Li, Weiqian Lou, Xichen Zhu, Qing Xie, Rongtao Lai Published online: August 5, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00447

Berberine Attenuates Hepatic Sinusoidal Obstruction Syndrome by Inhibiting Endothelial-mediated Neutrophil Recruitment and Activation Yiken Lin, Wenjia Tian, Weiming Dai, Ning Chen, Huifeng Hao, Yulan Liu Published online: July 20, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00024

Liver Failure, Cirrhosis and Portal Hypertension

Plasma Metabolites for Identifying Bacterial Infection in Acute-on-chronic Liver Failure: A Prospective Multicenter Study Xiaotian Yang, Hai Li, Yan Huang, Guohong Deng, Beiling Li, Xianbo Wang, Zhongji Meng, Yubao Zheng, Yanhang Gao, Zhiping Qian, Feng Liu, Xiaobo Lu, Yu Shi, Jia Shang, Jing Liu, Hang Jia, Sumeng Li, Lining Guo, Xin Zheng Published online: August 3, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00384

Review Article

Reporting Completeness of Biliary Atresia Organoid Studies: A Scoping Review and Structured Audit Guantong Li, Dayan Sun, Dingding Wang, Shuangshuang Li, Kaiyun Hua, Yichao Gu, Yanan Zhang, Yong Zhao, Junmin Liao, Jinshi Huang Published online: August 26, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00352

Molecular Basis and Clinical Significance of the High-risk Phenotype of Hepatitis B Virus Genotype C Chenchen Huang, Zhongjian Liu, Jingyao Zhang, Tao Shen, Lei Sang Published online: July 27, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00247

Research Letter

qHBsAg Trajectories with Peg-IFNα-2b Add-on Therapy in Nucleos(t)ide Analog-experienced HBeAg-positive Chronic Hepatitis B Kezhen Hu, Yanzhen Bi, Xiaoying Li, Xiangzhong Liu, Haoxi Wang, Yong Zhou, Yongning Xin Published online: July 24, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00175