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Online First Articles
The online first articles are peer reviewed, accepted, and are ready for publication, with copyediting, typesetting, proofreading and author review. They have not been assigned to a journal issue; an article will be removed from this page once it is published in a coming issue.

Articles published online first are citable. To cite an article on this page, please refer to the following example:

Yi SG, Sadhu AR, Jones SL, Turner K, Monsour H, Donahue K, et al. The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation. J Clin Transl Hepatol. Published online: Sep 15, 2013. doi: 10.14218/JCTH.2013.00007.

Original Article

Metabolic Liver Diseases

Analysis of the Disease Spectrum Characteristics of Inherited Metabolic Liver Diseases in Two Hepatology Specialist Hospitals in Beijing over the Past 20 Years

Wei Hou, Yuanzhi Huang, Tang Shang, Zheng Wang, Wei Zhang, Kefi Wang, Yinjie Gao, Min Zhang, Sujun Zheng

Published online: March 21, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00030

Investigation of HO-1 Regulation of Liver Fibrosis Related to Nonalcoholic Fatty Liver Disease Through the SIRT1/TGF-ß/Smad3 Pathway

Mengjiao Sun, Xiaoqing Wu, Zhandong Lin, Congyue Zhang, Jiawei Cui, Yaoyao Mao, Yue Shi, Jiaming Zhang, Yuemin Nan

Published online: March 12, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00481

Intestinal Depletion of TM6SF2 Exacerbates High-fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis

Li-Zhen Chen, Yu-Rong Wang, Zhen-Zhen Zhao, Shou-Lin Zhao, Cong-Cong Min, Yong-Ning Xin

Published online: March 12, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00407

Infectious Hepatitis

Hydronidone for the Treatment of Liver Fibrosis Associated with Chronic Hepatitis B: Protocol for a Phase 3 Randomized Trial

Xiaobo Cai, Yin Qu, Wen Xie, Yanbin Wang, Mengyu Zhao, Ling Zhang, Ying Luo, Ping Yin, Jun Cheng, Lungen Lu

Published online: March 10, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00472

Liver Failure, Cirrhosis and Portal Hypertension

Improved Discrimination and Predictive Ability of Novel Prognostic Scores for Long-term Mortality in Hospitalized Patients with Cirrhosis

Sipu Wang, Gaoyue Guo, Han Wang, Xuqian Zhang, Wanting Yang, Jie Yang, Liping Wu, Chao Sun

Published online: March 11, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00004

Mitochondrial Membrane Potential of CD8+ T Cells Predicts Bacterial Infection and Rapid Development of Acute-on-chronic Liver Failure in Cirrhotic Patients

Xixuan Wang, Shuling Chen, Jing Fan, Yuxiang Gong, Hongli Liu, Lili Wang, Xiaoning Feng, Hui Zhou, Wenquan Zeng, Changhua Yi, Caiyun Zhang, Qingfang Xiong, Hao Ren, Yongfeng Yang

Published online: February 25, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00452

Hepatic and Biliary Neoplasia

CCNE1 Promotes the Progression of Hepatic Precancerous Lesion and the Malignant Phenotype of Hepatocellular Carcinoma

Kai Zhang, Xue Hu, Lichao Yao, Wenzhi Guo

Published online: April 28, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00428

FTO Promotes Hepatocellular Carcinoma Progression by Mediating m6A Modification of BUB1 and Targeting TGF-βR1 to Activate the TGF-β Signaling Pathway

Lin Zhang, Li Gan, Yuru Lin, Zhechuan Mei, Shengtao Liao

Published online: April 18, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00007

Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from In Vitro and In Vivo Studies

Tongtong Li, Xuan Shen, Tao Zhang, Jiaheng Ren, Wang Wang, Didi Wang, Pengxia Zhang

Published online: April 18, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00369

GTF3C2 Promotes the Proliferation of Hepatocellular Carcinoma Cells through the USP21/MEK2/ERK1/2 Pathway

Yani Wu, Yingnan Yang, Youju Zhang, Qiuran Xu, Dongsheng Huang, Kangsheng Tu

Published online: February 11, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00386

Liver Injury, Autoimmune, and Cholestatic Diseases

Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury

Zhu Yang, Yang Tai, Tian Lan, Chong Zhao, Jin-Hang Gao, Cheng-Wei Tang, Huan Tong

Published online: March 3, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00440

Review Article

Molecular and Histological Profiles and Relevant Imaging Signatures of Intrahepatic Cholangiocarcinoma

Huizhen Huang, Feng Chen

Published online: April 30, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00410

Non-variceal Extrahepatic Portosystemic Shunts: A Review of Pathogenesis, Diagnosis, and Treatment

Nicole M. Anastasio, George Y. Wu

Published online: March 14, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00315

Beyond the Cure: Navigating Hepatocellular Risk and Surveillance after Hepatitis C Eradication in the Direct-acting Antiviral Era

Chencheng Xie, Ashwani K. Singal

Published online: February 8, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00499

Hot Topic Commentary

Ketamine Hepatotoxicity: An Underappreciated Cause of Liver Damage - Analysis by RUCAM

Bianca Thakkar, George Y. Wu

Published online: April 11, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00478

Key Points and Future Directions from the 2024 Chinese Guidelines for Fatty Liver Disease

Maria Tampaki, Evangelos Cholongitas

Published online: March 27, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00051

Research Letter

Characteristics of a Chinese Cohort of Patients with Chronic Hepatitis C Infection (2019–2023) and a Case Report of Resistance-associated Substitutions to Sofosbuvir-velpatasvir Treatment

Hao Xiong, Shaokun Pan, Chaohui Zhou, Hong Shi, Youhua Xie, Jinsheng Guo

Published online: April 10, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00033

Corrigendum

Corrigendum: Ursolic Acid Modulates Estrogen Conversion to Relieve Inflammation in Metabolic Dysfunction-associated Steatotic Liver Disease via HSD17B14

Published online: April 28, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00414C

Consensus

Chinese Expert Consensus for the Management of Thrombocytopenia in Cirrhosis

Xiaoyuan Xu, Yujuan Guan, Jinghang Xu, Song Yang, Yifan Han, Jidong Jia, Yuemin Nan, Lai Wei, Zhongping Duan, Hui Zhuang

Published online: April 24, 2025

[ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00105

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