Subscribe
  • Original Article
  • OPEN ACCESS

Baseline Characteristics and Treatment Patterns of the Patients Recruited to the China Registry of Hepatitis B

  • Shan Shan1,
  • Hong You1,
  • Junqi Niu2,
  • Jia Shang3,
  • Wen Xie4,
  • Yuexin Zhang5,
  • Xun Li6,
  • Hong Ren7,
  • Hong Tang8,
  • Huiguo Ding9,
  • Xihong Wang10,
  • Yuemin Nan11,
  • Xiaoguang Dou12,
  • Tao Han13,
  • Lingyi Zhang14,
  • Xiaoqing Liu15,
  • Cunliang Deng16,
  • Jilin Cheng17,
  • Xiaozhong Wang18,
  • Qing Xie19,
  • Shumei Lin20,
  • Yan Huang21,
  • Youqing Xu22,
  • Yong Xiong23,
  • Wu Li24,
  • Xuebing Yan25,
  • Hongxin Piao26,
  • Wenxiang Huang27,
  • Qinghua Lu28,
  • Weijin Gong29,
  • Shiping Li30,
  • Xiaoxuan Hu31,
  • Xiaolan Zhang32,
  • Shourong Liu33,
  • Yufang Li34,
  • Dongliang Yang35,
  • Hai Li36,
  • Caixia Yang37,
  • Mingliang Cheng38,
  • Liaoyun Zhang39,
  • Huanwei Zheng40,
  • Xinhua Luo41,
  • Feng Lin42,
  • Lei Wang43,
  • Guanghua Xu44,
  • Xiaoyuan Xu45,
  • Lai Wei46,
  • Jinlin Hou47,
  • Zhongping Duan48,
  • Hui Zhuang49,
  • Xizhong Yang50,
  • Yuanyuan Kong51,*,
  • Jidong Jia1,* and
  • for the CR-HepB study group, Beijing, China
 Author information
Journal of Clinical and Translational Hepatology 2019;7(4):322-328

DOI: 10.14218/JCTH.2019.00052

Abstract

Background and Aims: Chronic hepatitis B virus (HBV) infection remains a major public health problem globally. Here, we describe the baseline characteristics and treatment profiles of HBV-infected patients recruited to the China Registry of Hepatitis B.

Methods: Inclusion criteria were patients with different stages of chronic HBV infection and complete key data. Exclusion criteria were patients with hepatocellular carcinoma. The baseline clinical, laboratory and treatment profiles were analyzed.

Results: Finally, 40,431 patients were included. The median age was 43 years, with 65.2% being men and 51.3% being positive for hepatitis B e antigen (HBeAg). The most common initial diagnosis was chronic hepatitis B (81.0%), followed by cirrhosis (9.3%), inactive carrier of hepatitis B surface antigen (HBsAg) (6.7%), and immune tolerant phase of hepatitis B infection (3.0%). Among the 21,228 patients who were on treatment, 88.0%, 10.0% and 2.0% received nucleos(t)ide analogues (NAs), interferon or combination of NAs and interferon, respectively. The proportion of patients who received preferred NAs (entecavir or tenofovir disoproxil fumarate) had increased from 13.5% in 2003 to 79.7% in 2016.

Conclusions: We concluded that middle-aged men accounted for most of the patients with chronic hepatitis B in this cross-sectional study. About half of the patients were HBeAg-positive. NAs were the most commonly used therapy, and use of the preferred NAs had steadily increased in the past decade.

Keywords

Hepatitis B, Treatment, Registry

Introduction

Universal vaccination against hepatitis B virus (HBV) in infants has achieved great success but chronic HBV infection remains a major public health problem globally.1 The 2017 World Health Organization (WHO) Global Hepatitis Report estimates that 257 million persons, or 3.5% of the population, are chronically infected by HBV,2 with the highest hepatitis B surface antigen (HBsAg) prevalence (6.2%) being in the Western Pacific region.3–5 Chronic HBV infection is associated with a considerable burden of liver morbidity and mortality, and can lead to cirrhosis, decompensation and hepatocellular carcinoma (HCC).6

In China, with high coverage of HBV vaccination in infants, the estimated prevalence of HBsAg declined to 6.1% in the general population.7,8 However, historical HBV endemicity built a large reservoir of chronically infected persons. It is estimated that there are more than 70 million persons with chronic HBV infection in China.3 To facilitate real-world clinical study of chronic HBV infection, we have established a national HBV registry platform, the China Registry of Hepatitis B (known as the CR-HepB),9 which was launched in July 2012. Currently, it consists of 47 tertiary hospitals in mainland China (ClinicalTrials.gov registry number: NCT03108794).9

In the present cross-sectional study, we described the demographic, baseline characteristics, and treatment profiles of patients recruited in CR-HepB from June 2012 through June 2017.

Methods

Data sources

The CR-HepB was launched in June 2012 but retrospectively captured data of patients from 2000. The current study retrieved data from CR-HepB registrants prospectively or retrospectively from June 2012 to June 2017. The key information includes patients’ age, gender, diagnosis, laboratory results, liver biopsy results, and antiviral treatment profiles.

Patient population

Inclusion criteria were patients with different stages of chronic HBV infection and available information on hepatitis B e-antigen (HBeAg) status and HBV DNA and alanine transaminase levels. Exclusion criteria were patients with HCC.

The diagnostic criteria for immune tolerant phase, HBeAg-positive chronic hepatitis B (CHB), HBeAg-negative CHB, inactive HBsAg carriers, cirrhosis, and HCC were in line with major international and national guidelines10 and described in our previous paper.9

Statistical analyses

We use proportions and percentages to describe the demographic and clinical characteristics of the patients. We present the proportions of patients by their age, sex, HBeAg status, diagnosis, liver biopsy results, and type(s) of treatment received. Descriptive statistics are expressed as medians, lower quartiles, and upper quartiles, or as a number and percentage of patients. All statistical analyses were performed using SPSS v19.0.

Results

After excluding 530 individuals with HCC, 40,431 patients with confirmed diagnoses of immune tolerant phase hepatitis B, CHB, inactive HBsAg carrier status, and cirrhosis were included in the present study (Fig. 1).

Flowchart of selection of patients.
Fig. 1.  Flowchart of selection of patients.

Demographic and clinical characteristics of patients

The demographic and clinical characteristics of the patients are shown in Table 1. The median age was 43 years, with a men-to-women ratio of 1.9. Overall, 51.3% were HBeAg-positive. Approximately 81.0% of the patients had initially been diagnosed with CHB, 9.3% with cirrhosis, 6.7% as inactive HBsAg carriers, and 3.0% with immune tolerant phase hepatitis B.

Table 1.

Demographic and baseline data of 40,431 patients with hepatitis B virus-related diseases

Overall, n = 40,431Immune tolerance phase, n = 1,214Inactive HBsAg carrier, n = 2,725Chronic hepatitis B, n = 32,740Cirrhosis, n = 3,752
Age in years43 (33, 53)33 (28, 41)39 (31, 49)43 (33, 52)55 (48, 63)
Sex
 Men, n (%)26,347 (65.2)610 (50.2)1522 (55.9)21,472 (65.6)2743 (73.1)
 Women, n (%)14084 (34.8)604 (49.8)1203 (44.1)11,268 (34.4)1,009 (26.9)
HBeAg-positive, n (%)20740 (51.3)1214 (100.0)0 (0)17936 (54.8)1590 (42.4)
HBV DNA (log10 IU/mL)3.9 (2.3, 6.6)7.6 (6.3, 8.1)0 (0, 2.6)4.2 (2.7, 6.9)3.9 (2.0, 5.6)
ALT (IU/mL)41.7 (24.6, 87.0)27.0 (21.0, 34.8)24.0 (18.0, 33.0)46.0 (26.0, 99.0)42.0 (27.0, 76.0)
AST (IU/mL)34.0 (23.0, 63.0)22.0 (17.0, 26.0)23.0 (19.0, 28.0)35.6 (24.0 67.2)47.0 (29.5.0,83.6)
ALP (U/L)78.0 (62.0, 101.0)69.0 (56.0, 85.0)70.0 (58.0, 86.0)77.7 (62.0, 99.0)97.8 (73.0, 133.0)
GGT (U/L)27.0 (16.0, 55.0)15.0 (12.0, 21.0)17.0 (12.0, 25.0)28.0 (17.0, 55.2)50.9 (27.9, 99.0)
Bilirubin (μmol/L)14.8 (10.9, 21.5)12.1 (9.3, 15.8)12.8 (9.7, 17.2)14.4 (10.8, 20.3)24.5 (15.9, 41.3)
ALB (g/L)44.0 (39.7, 46.7)45.2 (43.2, 47.3)45.4 (43.4, 47.4)44.2 (40.4, 46.9)34.8 (29.4, 41.2)
PLT count (×109/L)165.0 (115.0, 208.3)200.0 (173.0, 236.0)188.0 (154.0, 225.0)171.0 (129.0, 211.0)81.0 (53.0, 123.0)

Data are expressed as median (range) or n (%).

Abbreviations: ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; PLT, platelet.

Age distribution of the 40,431patients with chronic HBV infection (by sex)

Among the 40,431 patients included in the present study, the 30–49 years-old age group was the most predominant in both men and women, followed by the 50–59 years-old age group. Patients aged between 30–59 years-old accounted for 71.8% of all patients (Fig. 2).

Age distribution of chronic hepatitis B virus infection by sex in 40,431 patients.
Fig. 2.  Age distribution of chronic hepatitis B virus infection by sex in 40,431 patients.

Disease distribution in different age groups among the 40,431 patients

The proportion of patients diagnosed with cirrhosis was increased with increasing ages, whereas the proportion of patients diagnosed with immune tolerance phase was decreased with increasing age (Fig. 3).

Disease distribution in different age groups among the 40,431 patients.
Fig. 3.  Disease distribution in different age groups among the 40,431 patients.

Liver histology of 485 patients

Necroinflammation activity and fibrosis stage were assessed according to the Scheuer grading and staging system.11 Among the 485 patients who underwent liver biopsy, the proportion of patients with liver inflammation grade ≥2 or the stage of liver fibrosis ≥2 increased with age (Fig. 4).

Distribution of (A) the necroinflammation grade and (B) fibrosis stage in 485 patients.
Fig. 4.  Distribution of (A) the necroinflammation grade and (B) fibrosis stage in 485 patients.

Treatment profiles of 21,228 patients and the changing prescription of different nucleos(t)ide analogues

Nucleos(t)ide analogues (NAs) were the most common therapy among the 21,228 patients with prescription information. A much smaller proportion of patients were treated with interferon (10.0%) or a combination of interferon and NAs (2.0%).

Lamivudine (15.3%) and adefovir dipivoxil (18.4%) were widely used before 2011, whereas the use of entecavir (51.4%) and tenofovir disoproxil fumarate (2.1%) dramatically increased after 2011 (Fig. 5).

Changes in proportion of each nucleos(t)ide analogue use, 2003–2016.
Fig. 5.  Changes in proportion of each nucleos(t)ide analogue use, 2003–2016.

Discussion

In the present study, with large number of patients, we found that middle-aged men represented the major proportion of this cohort. About half of the patients were HBeAg-positive. The most common initial diagnosis was CHB, followed by cirrhosis, inactive HBsAg carrier, and immune tolerant phase of hepatitis B infection. The proportion of patients diagnosed with cirrhosis was increasing with increasing age. Among the patients with prescription information, nearly 90% received NAs and the use of preferred NAs have increased dramatically in the past decade.

Our study showed that men accounted for a significantly higher proportion (65.2%) than women (34.8%), and about half of patients were HBeAg-positive. This is similar to the result of a recent multicenter, real-world study conducted in tier-2 city hospitals in China, which showed that 74% of 3,408 patients with CHB were men, with an overall mean age of 40 years, and that 60% of patients were HBeAg-positive.12 Not surprisingly, patients with HBeAg-negative infection were older than those with HBeAg-positive infection, also similar to that reported from the USA.13

In our study, the middle-aged group was the most predominant in both men and women. This is in line with the recent reports that the prevalence of HBsAg in childbearing-aged men and women still being around 6% in rural and endemic areas in China.14 Therefore, prevention of mother-to-child transmission is still of paramount importance.3,15,16

Not surprisingly, the proportion of patients diagnosed with cirrhosis was increased with increasing age. Similarly, among the 485 patients who underwent liver biopsy, the majority of these patients had mild to moderate necroinflammation and fibrosis. This may be due to the fact that patients with more disease activity and advanced fibrosis could be identified easily by noninvasive modalities, making them under-represented among patients who received liver biopsy.

In our study, more than half of the patients were prescribed treatment, and nearly 90% of them received NAs due to their favorable efficacy and safety as well as ease of administration. All major international guidelines recommend highly potent entecavir and tenofovir disoproxil fumarate as preferred therapy,10,17–19 since accumulating evidence indicates that long-term therapy with entecavir or tenofovir disoproxil fumarate can prevent or reverse liver fibrosis and reduce risk of HCC.20–22 However, in real-world practice, lots of patients had been treated with lamivudine, adefovir dipivoxil and telbivudine, which are not preferred therapy, due to their low antiviral potency and low genetic barrier. This discrepancy between guideline recommendations and real-world clinical practice may be influenced by many factors, including doctors’ knowledge, reimbursement policy, and patients’ economic status and compliance.22–24

Fortunately, this study showed the prescription of different NAs has favorably changed in the past years, with entecavir prescription increased from less than one-third to more than half. This trend may reflect the following facts: 1) evidence from clinical trial and real-world studies convincingly demonstrates the efficacy and safety of antiviral therapy,12,25,26 2) update of evidence-based national guidelines recommends entecavir and tenofovir disoproxil fumarate as first-line therapy,10 3) evolving national and local reimbursement policy offers more potent antiviral therapy for people who are covered by basic social medical insurance. All these improved the standard of care in clinical practice for CHB treatment. Tenofovir disoproxil fumarate was used only in less than 10%, simply because it had not been proved for HBV until mid-2014 in mainland China.

We hope this large nationwide database could provide a point of view of clinical profiles of chronic HBV infection and the treatment landscape in mainland China. However, several limitations in our study need to be mentioned. First, since CR-HepB is a hospital-based registry system, the proportion of inactive HBsAg carriers may be underestimated, as these patients are usually asymptomatic and may not seek medical service. Second, the cross-sectional design made it difficult to identify factors associated with disease progression or regression. However, CR-HepB registrants are advised to received follow-up visits every 3 to 6 months, so we could expect this limitation may be solved in the future. A final limitation is potential selection bias, as the majority of patients in the CR-HepB are from tertiary hospitals, therefore not necessarily reflecting the clinical practice in secondary or primary medical care settings where the resources and expertise are far less privileged.

Conclusions

In conclusion, this hospital-based cross-sectional study provides a snapshot of demographic and baseline profiles of Chinese patients with different stage of chronic HBV infection, as well as the landscape of clinical management.

Ethics Approval

The registry protocol was reviewed and approved by the ethics committee of Beijing Friendship Hospital, Capital Medical University (Approval Number: BJFH-EC/2014-044). Each participating institution also obtained approval from its institutional ethics committee.

Abbreviations

CHB: 

chronic hepatitis B

CR-HepB: 

China Registry of Hepatitis B

HBeAg: 

hepatitis B e-antigen

HBsAg: 

hepatitis B surface antigen

HBV: 

hepatitis B virus

HCC: 

hepatocellular carcinoma

NAs: 

nucleos(t)ide analogues

WHO: 

World Health Organization

Declarations

Acknowledgement

We thank the China Foundation for Hepatitis Prevention and Control, Chinese Society of Hepatology, Chia Tai-Tianqing Pharmaceutical Group Co., Ltd and Shanghai Ashermed Healthcare Communications, Ltd, for their administrative coordination, technical assistance, and unrestricted grant to the CR-HepB and this paper.

Conflict of interest

The authors have no conflict of interests related to this publication.

Authors’ contributions

Designed the study (JJ, HY, HZ, LW, JH, ZD), drafted the manuscript (SS), data management (YK). Served as the project leader and extensively and critically revised this manuscript (JJ). The other authors are the team members. All authors have read and approved the final version of the manuscript.

References

  1. Naghavi M, Wang H, Lozano R, Davis A, Liang X, Zhou M. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;385:117-171 View Article PubMed/NCBI
  2. Global hepatitis report, 2017. Available from: https://apps.who.int/iris/bitstream/handle/10665/255016/9789241565455-eng.pdf;jsessionid=7DA50E712691FED09098855C3796A3A7?sequence=1 View Article PubMed/NCBI
  3. Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 2015;386:1546-1555 View Article PubMed/NCBI
  4. Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012;30:2212-2219 View Article PubMed/NCBI
  5. Tian Q, Jia J. Hepatitis B virus genotypes: epidemiological and clinical relevance in Asia. Hepatol Int 2016;10:854-860 View Article PubMed/NCBI
  6. Stanaway JD, Flaxman AD, Naghavi M, Fitzmaurice C, Vos T, Abubakar I. The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013. Lancet 2016;388:1081-1088 View Article PubMed/NCBI
  7. Liang X, Bi S, Yang W, Wang L, Cui G, Cui F. Reprint of: Epidemiological serosurvey of Hepatitis B in China--declining HBV prevalence due to Hepatitis B vaccination. Vaccine 2013;31:J21-J28 View Article PubMed/NCBI
  8. Cui F, Shen L, Li L, Wang H, Wang F, Bi S. Prevention of chronic hepatitis B after 3 decades of escalating vaccination policy, China. Emerg Infect Dis 2017;23:765-772 View Article PubMed/NCBI
  9. Shan S, Wei W, Kong Y, Niu J, Shang J, Xie W. China Registry of Hepatitis B (CR-HepB): Protocol and implementation of a nationwide hospital-based registry of hepatitis B. Scand J Public Health 2018:1403494818772188 View Article PubMed/NCBI
  10. Hou J, Wang G, Wang F, Cheng J, Ren H, Zhuang H. Guideline of prevention and treatment for chronic hepatitis B (2015 update). J Clin Transl Hepatol 2017;5:297-318 View Article PubMed/NCBI
  11. Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991;13:372-374 View Article PubMed/NCBI
  12. Jia J, Tang H, Ning Q, Jiang J, Dou X, Zhang M. Real-world evidence for nucleoside/nucleotide analogues in a 5-year multicentre study of antiviral-naive chronic hepatitis B patients in China: 52-week results. Antivir Ther 2018;23:201-209 View Article PubMed/NCBI
  13. Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Teshale ET. Distribution of disease phase, treatment prescription and severe liver disease among 1598 patients with chronic hepatitis B in the Chronic Hepatitis Cohort Study, 2006–2013. Aliment Pharmacol Ther 2016;44:1080-1089 View Article PubMed/NCBI
  14. He T, Jia J. Chronic HBV: which pregnant women should be treated?. Liver Int 2016;36:105-108 View Article PubMed/NCBI
  15. Cui F, Liang X, Gong X, Chen Y, Wang F, Zheng H. Preventing hepatitis B though universal vaccination: reduction of inequalities through the GAVI China project. Vaccine 2013;31:J29-J35 View Article PubMed/NCBI
  16. Liu J, Zhang S, Wang Q, Shen H, Zhang M, Zhang Y. Seroepidemiology of hepatitis B virus infection in 2 million men aged 21–49 years in rural China: a population-based, cross-sectional study. Lancet Infect Dis 2016;16:80-86 View Article PubMed/NCBI
  17. Terrault NA, Lok ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology 2018;67:1560-1599 View Article PubMed/NCBI
  18. Lampertico P, Agarwal K, Berg T, Buti M, Janssen HLA, Papatheodoridis G. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol 2017;67:370-398 View Article PubMed/NCBI
  19. Sarin SK, Kumar M, Lau GK, Abbas Z, Chan HL, Chen CJ. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int 2016;10:1-98 View Article PubMed/NCBI
  20. Varbobitis I, Papatheodoridis GV. The assessment of hepatocellular carcinoma risk in patients with chronic hepatitis B under antiviral therapy. Clin Mol Hepatol 2016;22:319-326 View Article PubMed/NCBI
  21. Papatheodoridis GV, Chan HL, Hansen BE, Janssen HL, Lampertico P. Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy. J Hepatol 2015;62:956-967 View Article PubMed/NCBI
  22. Sun Y, Zhou J, Wang L, Wu X, Chen Y, Piao H. New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment. Hepatology 2017;65:1438-1450 View Article PubMed/NCBI
  23. Lim SG, Amarapurkar DN, Chan HL, Crawford DH, Gane EJ, Han KH. Reimbursement policies in the Asia-Pacific for chronic hepatitis B. Hepatol Int 2015;9:43-51 View Article PubMed/NCBI
  24. Shan S, Cui F, Jia J. How to control highly endemic hepatitis B in Asia. Liver Int 2018;38:122-125 View Article PubMed/NCBI
  25. Wei L, Jia JD, Weng XH, Dou XG, Jiang JJ, Tang H. Treating chronic hepatitis B virus: Chinese physicians’ awareness of the 2010 guidelines. World J Hepatol 2016;8:762-769 View Article PubMed/NCBI
  26. Zeng N, Zou C, He Z, Ma H, Ou X, You H. Systematic review on the reporting quality of randomized controlled trials in patients with hepatitis B or C in China. Int J Infect Dis 2018;67:58-64 View Article PubMed/NCBI

Copyright © 2022 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • Journal of Clinical and Translational Hepatology
  • pISSN 2225-0719
  • eISSN 2310-8819

Download PDF

Metrics

Article accesses:
11018

Citation

Order Reprints
  • Copyright © 2022 JCTH. All Rights Reserved.
  • Published by Xia & He Publishing Inc.
  • Address: 14090 Southwest Freeway, Suite 300, Sugar Land, Texas 77478, USA
  • Email: service@xiahepublishing.com