Original Article

Liver Failure, Cirrhosis and Portal Hypertension

PDK4 Regulates Inflammatory Injury in Acute-on-chronic Liver Failure by Phosphorylating STAT1-mediated M1 Polarization of Macrophages Shilong Dong, Luyuan Ma, Chuan Shen, Ruolan Gu, Xinyang Li, Ying Xiao, Caiyan Zhao Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00343

Hepatic and Biliary Neoplasia

Centromere Protein I, a Cell Cycle Checkpoint Gene, Accelerates Tumor Progression via the Hippo Pathway and Mediates Immune Escape in Hepatocellular Carcinoma Risheng He, Yi Xu, Pengbo Zhang, Liang Yu, Jian Ma, Yunfu Cui Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00127

Liver Injury, Autoimmune, and Cholestatic Diseases

Fecal Microbiome and Bile Acid Profiles Differ in Preterm Infants with Parenteral Nutrition-associated Cholestasis Ellen S. Wagner, Kaitlyn Oliphant, Mark D’Souza, Wilfredo Cruz-Ayala, Ruba K. Azzam, Bree Andrews, Erika C. Claud Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00152

Review Article

Nutrient-stimulated Hormone-based Therapies: A New Frontier in the Prevention and Management of MASH-associated Hepatocellular Carcinoma Richard Phillips, Yuk Ting Ma, Wasim Hanif, Tahir Shah, Shivan Sivakumar Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00303

Protein Induced by Vitamin K Absence or Antagonist II in Primary Liver Cancer: Basic Research Insights and Clinical Applications Xin Zhang, Rong Wang, Bin Niu, Liaoyun Zhang Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00377

Current and Emerging Issues in Familial Hypobetalipoproteinemia-related Steatotic Liver Diseases Tian-Wen Lou, Tian-Yi Ren, Jian-Gao Fan Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00360

Quality and Quantity? The Clinical Significance of Myosteatosis in Various Liver Diseases: A Narrative Review Jie Yang, Qing Liu, Chao Sun Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00383

Consensus

Expert Consensus on Clinical Applications of Fecal Microbiota Transplantation for Chronic Liver Disease (2025 edition) Yongjian Zhou, Li Yang, Yuemin Nan, Liver Related Digestive Diseases Group, Chinese Society of Hepatology, Chinese Medical Association Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00456

Illuminating and Instructive Clinical Case

Human Albumin-enriched Peritoneal Dialysis: A Novel Approach to Manage Refractory Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease Mario Romeo, Silvio Borrelli, Marcello Dallio, Carlo Garofalo, Fiammetta Di Nardo, Paolo Vaia, Carmine Napolitano, Luca De Nicola, Alessandro Federico Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00404

Research Letter

Longitudinal Profile of HBsAg Isoforms and Circulating Immune Complexes in the Natural History of Chronic Hepatitis B Infection Lung-Yi Mak, Mark Anderson, Tiffany Fortney, Danny Ka-Ho Wong, Rex Wan-Hin Hui, Wai-Kay Seto, Gavin Cloherty, Man-Fung Yuen Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00379

Screening for Mutations Causing ACOX2 Deficiency-associated Hypertransaminasemia in Patients with Cryptogenic Liver Injury Elisa Herraez, Maria J. Monte, Marta Alonso-Peña, Jesus Prieto, Luis Bujanda, Milagros Muñoz-Chimeno, Ana Avellon, Jose J.G. Marin Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00329

Reviewer Acknowledgement

2025 Reviewer Acknowledgement Editorial Office of Journal of Clinical and Translational Hepatology Published online: December 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.000RA