Original Article

Infectious Hepatitis

Chronic Hepatitis B in the Asia-Pacific Region: Results of the 2023 Global Burden of Disease Study Zhengzhao Lu, Dong Xu, Wei Ji, Jingjie Zhao, Tingting Xiao, Dongxu Wang, Yuanyuan Kong, Jidong Jia, Hong You, Xinyu Zhao Published online: June 26, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00114

Metabolic Liver Diseases

Regional Inequities in Metabolic Dysfunction–associated Steatotic Liver Disease Burden and Care Quality in High-burden Settings: Implications for Health Systems Kexin Zhang, Chengxia Kan, Sufang Sheng, Wei Xu, Fang Han, Jian Chen, Xuan Li, Ningning Hou, Ying Xue, Xiaodong Sun Published online: June 22, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00127

Liver Failure, Cirrhosis and Portal Hypertension

GSTM3 Knockdown Promotes Liver Fibrosis Reversal by Inhibiting Hepatic Stellate Cell Activation via PPARγ Signaling Chenxue Hou, Bingqing Yang, Yuanying Zhao, Hao Chang, Tong Bu, Qi Wang, Yue Li Published online: May 25, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00658

Liver Injury, Autoimmune, and Cholestatic Diseases

A Dual Time Window-driven Strategy to Optimize Primary Biliary Cholangitis Treatment via Alkaline Phosphatase Normalization Han Zhao, Yansheng Liu, Yingmei Tang, Ningning Wang, Yanmin Liu, Yiling Li, Chunyang Huang, Jieting Duan, Yan Feng, Linhua Zheng, Ruiqing Sun, Xiufang Wang, Juan Deng, Gui Jia, Patrick S.C. Leung, M. Eric Gershwin, Yulong Shang, Ying Han Published online: May 15, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00082

A Multi-omics and Machine Learning Framework Identifies Plasma SBDS as a Causal Biomarker and Therapeutic Target in Primary Sclerosing Cholangitis Pengfei Cheng, Yuanming Qiang, Yibo Sun, Binwei Duan, Yabo Ouyang, Guangming Li Published online: March 20, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00676

Hepatic and Biliary Neoplasia

Targeting the 4EBP1/HSP90β/Nrf2 Axis Sensitizes β-catenin-mutant Hepatocellular Carcinoma to mTOR Inhibitors via Ferroptosis Induction Rong Li, Yi Zhou, Zimu Wang, Gang Liu, Deyu Fan, Lanxuan Huang, Fule Deng, Ning Wei, Runze Shang, Meng Xu Published online: June 16, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00072

Review Article

Antimitochondrial Antibody Measurements in the Diagnosis of Antimitochondrial Antibody-negative and Alkaline Phosphatase-positive Primary Biliary Cholangitis: An Update and Review Karol Suchowiecki, George Y. Wu Published online: June 23, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00117

Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review Nikolaos T. Pyrsopoulos, Nadege Gunn, Prasun K. Jalal, George E. Catinis Published online: May 8, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00698

Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B Siqi Sun, Sisi Yang, Yihe Yu, Jiyang Chen, Jintao Ning, Yida Yang, Hongyu Jia Published online: April 28, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00118

Letter to the Editor

Letter to the Editor: Genotype-specific Response to 144-week Entecavir Therapy for HBeAg-positive Chronic Hepatitis B with a Particular Focus on Histological Improvement: A Prospective Study Chenhao Ye, Lei Wang Published online: April 27, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00159