Editorial

Unraveling the Dynamic Role of Microtubules in the HBV Life Cycle Urania Georgopoulou, John Koskinas Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00135

Hot Topic Commentary

Acute Severe Hepatitis of Unknown Origin in Children Across the World: A 2022 Source of Concern Lampros Chrysavgis, Evangelos Cholongitas Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00252

Original Article

Metabolic Liver Diseases

PNPLA3 rs738409 C>G Variant Influences the Association Between Visceral Fat and Significant Fibrosis in Biopsy-proven Nonalcoholic Fatty Liver Disease Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Ou-Yang Huang, Rafael S. Rios, Kenneth I. Zheng, Sui-Dan Chen, Hong-Lei Ma, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00286

Infectious Hepatitis

Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study Qiqi Zhang, Hui Huang, Aijun Sun, Chunyan Liu, Zhidong Wang, Feifan Shi, Wei Duan, Xueying Sun, Qi Wang, Ping Sun, Chunwen Pu, Yong Zhang Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00160

Clinical Predictors of Functional Cure in Children 1–6 Years-old with Chronic Hepatitis B Jing Pan, Haiyan Wang, Tiantian Yao, Xuejiao Liao, Hao Cheng, Suthat Liangpunsakul, Yan Wang, Min Zhang, Zheng Zhang Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00142

Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China Xinyu Zhao, Min Li, Hao Wang, Xiaoqian Xu, Xiaoning Wu, Yameng Sun, Canjian Ning, Bingqiong Wang, Shuyan Chen, Hong You, Jidong Jia, Yuanyuan Kong Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00167

Hepatitis B Virus Induces Microtubule Stabilization to Promote Productive Infection through Upregulating Microtubule-associated Protein 1S Yuanyue Guan, Bin Sun, Shijie Zhang, Yuan Zhuang, Yanxiang Huang, Minghua Lin, Rongling Zheng, Dexi Chen, Ying Shi, Yanjun Wang Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00090

DILI, Autoimmune, and Cholestatic Diseases

Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome Yimei Liu, Ninghua Liu, Yujing Liu, Hongyu He, Zhe Luo, Wenjun Liu, Nan Song, Minjie Ju Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00072

Liver Failure, Cirrhosis and Portal Hypertension

Racial and Health Disparities among Cirrhosis-related Hospitalizations in the USA Ashwani K. Singal, Yong-Fang Kuo, Juan P. Arab, Ramon Bataller Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00227

Advantages of a Novel Model for Predicting Hepatic Fibrosis in Chronic Hepatitis B Virus Carriers Compared with APRI and FIB-4 Scores Na-Ling Kang, Qing-Fa Ruan, De-Sheng Zhang, Xue-Ping Yu, Zhen-Ting Hu, Zhi-Min Lin, Lu-Ying Wu, Meng-Xin Lin, Zu-Xiong Huang, Jia-Ji Jiang, Yu-Rui Liu, Ri-Cheng Mao, Da-Wu Zeng Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00098

Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF Jingjing Tong, Mingjie Yao, Xiuying Mu, Leijie Wang, Xiajie Wen, Xingran Zhai, Xiang Xu, Yu Wang, Jing Chen, Xiangwei Zhai, Chongdan Guan, Fengmin Lu, Jinhua Hu Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2020.00133

Development and Validation of a Nomogram for 90-day Outcome in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure Jun Yang, Ran Xue, Jing Wu, Lin Jia, Juan Li, Hongwei Yu, Yueke Zhu, Jinling Dong, Qinghua Meng Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00202

Hepatic and Biliary Neoplasia

Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo Fanghua Qiu, Huajing Long, Lu Zhang, Jieyuan Liu, Zetian Yang, Xianzhang Huang Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00108

Review Article

Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies Nelia Hernandez, Fernando Bessone Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00243

Tumor-associated Exosomes Are Involved in Hepatocellular Carcinoma Tumorigenesis, Diagnosis, and Treatment Hang Wang, Liang Yu, Peng Huang, Yongxu Zhou, Wangyang Zheng, Nanfeng Meng, Risheng He, Yi Xu, Tey Sze Keong, Yunfu Cui Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00425

Pediatric Acute Severe Hepatitis of Unknown Origin: What is New? Jing Li, Wei Hu, Ji-Yuan Zhang, Fu-Sheng Wang Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00247

Update on Sphincter of Oddi Dysfunction: A Review Jaimy Villavicencio Kim, George Y. Wu Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00167

Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak Li-Ya Zhang, Li-Su Huang, Yu-Hang Yue, Rima Fawaz, Joseph K. Lim, Jian-Gao Fan Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2022.00281

Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review Teresa Da Cunha, Haleh Vaziri, George Y. Wu Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00344

Statin-induced Liver Injury Patterns: A Clinical Review Leon D. Averbukh, Alla Turshudzhyan, David C. Wu, George Y. Wu Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00271

Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00250

Case Report

Imaging Findings of Hepatic Ewing’s Sarcoma on Computed Tomography and Gadobenate Dimeglumine-enhanced Magnetic Resonance Imaging: A Case Report and Literature Review Tao Lu, Wenhao Yang, Xingchao Liu, Xudan Yang, Chong Yang, Wenjia Di Published online: June 28, 2022 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2021.00129