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Table of Contents
Editorial
Ariadne’s Thread in the Network of Hepatocellular Carcinoma Immunobiology
John Koskinas, Athanasios Armakolas
[ Abstract ] [ Html ] [ PDF Full-text ] 279-280 Doi: 10.14218/JCTH.2021.00140
Prediction and Prevention of Post-hepatectomy Liver Failure: Where Do We Stand?
Amr Shaaban Hanafy
[ Abstract ] [ Html ] [ PDF Full-text ] 281-282 Doi: 10.14218/JCTH.2021.00144
Original Article
PD-1 Involvement in Peripheral Blood CD8+ T Lymphocyte Dysfunction in Patients with Acute-on-chronic Liver Failure
Xiaoshuang Zhou, Yidong Li, Yaqiu Ji, Tian Liu, Ninghui Zhao, Jiefeng He, Jia Yao
[ Abstract ] [ Html ] [ PDF Full-text ] 283-290 Doi: 10.14218/JCTH.2020.00142
Development and Validation of a Nomogram Based on Perioperative Factors to Predict Post-hepatectomy Liver Failure
Bin Xu, Xiao-Long Li, Feng Ye, Xiao-Dong Zhu, Ying-Hao Shen, Cheng Huang, Jian Zhou, Jia Fan, Yong-Jun Chen, Hui-Chuan Sun
[ Abstract ] [ Html ] [ PDF Full-text ] 291-300 Doi: 10.14218/JCTH.2021.00013
Integrative Characterization of Immune-relevant Genes in Hepatocellular Carcinoma
Wei-Feng Hong, Yu-Jun Gu, Na Wang, Jie Xia, Heng-Yu Zhou, Ke Zhan, Ming-Xiang Cheng, Ying Cai
[ Abstract ] [ Html ] [ PDF Full-text ] 301-314 Doi: 10.14218/JCTH.2020.00132
Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging
Weixia Li, Ruokun Li, Xiangtian Zhao, Xiaozhu Lin, Yixing Yu, Jing Zhang, Kemin Chen, Weimin Chai, Fuhua Yan
[ Abstract ] [ Html ] [ PDF Full-text ] 315-323 Doi: 10.14218/JCTH.2020.00173
3-year Treatment of Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China
Jinlin Hou, Qin Ning, Zhongping Duan, You Chen, Qing Xie, Fu-Sheng Wang, Lunli Zhang, Shanming Wu, Hong Tang, Jun Li, Feng Lin, Yongfeng Yang, Guozhong Gong, John F. Flaherty, Anuj Gaggar, Shuyuan Mo, Cong Cheng, Gregory Camus, Chengwei Chen, Yan Huang, Jidong Jia, Mingxiang Zhang, GS-US-320-0110 and GS-US-320-0108 China Investigators
[ Abstract ] [ Html ] [ PDF Full-text ] 324-334 Doi: 14218/JCTH.2020.00145
Tenofovir Alafenamide Fumarate, Tenofovir Disoproxil Fumarate and Entecavir: Which is the Most Effective Drug for Chronic Hepatitis B? A Systematic Review and Meta-analysis
Xuefeng Ma, Shousheng Liu, Mengke Wang, Yifen Wang, Shuixian Du, Yongning Xin, Shiying Xuan
[ Abstract ] [ Html ] [ PDF Full-text ] 335-344 Doi: 10.14218/JCTH.2020.00164
Validation of the Nanjing Criteria for Diagnosing Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstruction Syndrome
Wei Zhang, Lu Liu, Ming Zhang, Feng Zhang, Chunyan Peng, Bin Zhang, Jun Chen, Lin Li, Jian He, Jiangqiang Xiao, Yanhong Feng, Xunjiang Wang, Aizhen Xiong, Li Yang, Xiaoping Zou, Yuecheng Yu, Yuzheng Zhuge
[ Abstract ] [ Html ] [ PDF Full-text ] 345-352 Doi: 10.14218/JCTH.2020.00124
Efficacy of Intragastric Balloons in the Markers of Metabolic Dysfunction-associated Fatty Liver Disease: Results from Meta-analyses
Zi-Yuan Zou, Jing Zeng, Tian-Yi Ren, Yi-Wen Shi, Rui-Xu Yang, Jian-Gao Fan
[ Abstract ] [ Html ] [ PDF Full-text ] 353-363 Doi: 10.14218/JCTH.2020.00183
Roles of SET7/9 and LSD1 in the Pathogenesis of Arsenic-induced Hepatocyte Apoptosis
Bing Han, Yi Yang, Lei Tang, Qin Yang, Rujia Xie
[ Abstract ] [ Html ] [ PDF Full-text ] 364-372 Doi: 10.14218/JCTH.2020.00185
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK
Yue Wu, Ying Yang, Fang Li, Jie Zou, Yu-Hao Wang, Meng-Xia Xu, Yong-Lun Wang, Rui-Xi Li, Yu-Ting Sun, Shun Lu, Yuan-Yuan Zhang, Xiao-Dong Sun
[ Abstract ] [ Html ] [ PDF Full-text ] 373-383 Doi: 10.14218/JCTH.2021.00050
Predictive Value of Inflammation Biomarkers in Patients with Portal Vein Thrombosis
Jian-Bo Han, Qing-Hua Shu, Yu-Feng Zhang, Yong-Xiang Yi
[ Abstract ] [ Html ] [ PDF Full-text ] 384-391 Doi: 10.14218/JCTH.2020.00159
Characteristics and Inpatient Outcomes of Primary Biliary Cholangitis and Autoimmune Hepatitis Overlap Syndrome
Yi Jiang, Bing-Hong Xu, Brandon Rodgers, Nikolaos Pyrsopoulos
[ Abstract ] [ Html ] [ PDF Full-text ] 392-398 Doi: 10.14218/JCTH.2021.00008
Review Article
HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site
Dake Zhang, Ke Zhang, Urlike Protzer, Changqing Zeng
[ Abstract ] [ Html ] [ PDF Full-text ] 399-408 Doi: 10.14218/JCTH.2021.00062
A Review of Hepatitis B Virus and Hepatitis C Virus Immunopathogenesis
Corey Saraceni, John Birk
[ Abstract] [ Html ] [ PDF Full-text ] 409-418 Doi: 10.14218/JCTH.2020.00095
Direct-acting Antiviral Regimens for Patients with Chronic Infection of Hepatitis C Virus Genotype 3 in China
Xiaozhong Wang, Lai Wei
[ Abstract ] [ Html ] [ PDF Full-text ] 419-427 Doi: 10.14218/JCTH.2020.00097
Nonalcoholic Fatty Liver Disease after Liver Transplant
Akshay Shetty, Fanny Giron, Mukul K. Divatia, Muhammad I. Ahmad, Sudha Kodali, David Victor
[ Abstract ] [ Html ] [ PDF Full-text ] 428-435 Doi: 10.14218/JCTH.2020.00072
Current and New Drugs for COVID-19 Treatment and Its Effects on the Liver
Sandeep Satsangi, Nitin Gupta, Parul Kodan
[ Abstract ] [ Html ] [ PDF Full-text ] 436-446 Doi: 10.14218/JCTH.2020.00174
Case Report
Acute-on-chronic Liver Failure in a Patient with Candida Endophthalmitis: A Case Report
Ying Cao, Ying Fan, Yanbin Wang, Xiyao Liu, Wen Xie
[ Abstract ] [ Html ] [ PDF Full-text ] 447-451 Doi: 10.14218/JCTH.2020.00092
CASE REPORT
Acute-on-chronic Liver Failure in a Patient with Candida Endophthalmitis: A Case Report
Ying Cao1 , Ying Fan1 , Yanbin Wang1 , Xiyao Liu2 and Wen Xie1,*
1 Center of Liver Diseases, Capital Medical University Affiliated to Beijing Ditan Hospital, Beijing, China
2 Department of Ophthalmology, Capital Medical University Affiliated to Beijing Ditan Hospital, Beijing, China
*Correspondence to: Wen Xie, Center of Liver Diseases, Capital Medical University Affiliated to Beijing Ditan Hospital, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, China. ORCID:https://orcid.org/0000-0002-7314-8175. Tel: +86-10-84322816, Fax: +86-10-84322818, E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.
Journal of Clinical and Translational Hepatology 2021;9(3):447-451 DOI: 10.14218/JCTH.2020.00092
Received: October 11, 2020 Accepted: March 1, 2021 Published online: March 30, 2021
Abstract
Acute-on-chronic liver failure (ACLF) is a risk factor for fungal infection. Endogenous fungal endophthalmitis is a serious, sight-threatening disease. Common causes include immunocompromised state and intravenous drug use, permitting opportunistic pathogens to reach the eye through the blood stream. We report a case of Candida endophthalmitis in a 47 year-old woman who was admitted to our hospital with ACLF and poorly controlled diabetes. In addition, she was treated with glucocorticoids due to severe jaundice. After treatment for ACLF, the patient experienced fever with blurred vision in the left eye and was diagnosed with candidemia, endogenous Candida endophthalmitis in the left eye, and chorioretinitis in the right eye. Systemic and topical antifungal treatment was administered based on the positive Candida albicans test in intraocular fluid using second-generation sequencing. The patient underwent vitrectomy in the left eye and C. albicans was confirmed in vitreous cultures. Follow-up visit, at 6 weeks after the operation, showed only light perception in the left eye and stable visual acuity in the right eye. Physicians should be aware of endogenous fungal endophthalmitis in patients with ACLF, especially those with Candida infection, a history of glucocorticoid use, and diabetes. A dilated retinal examination should be performed by an ophthalmologist if ACLF patients develop fever and fungal infection.
Keywords
Acute-on-chronic liver failure, Candida endophthalmitis, Candida albicans, Glucocorticoid, Case report
Journal of Clinical and Translational Hepatology 2021 vol. 9, 447-451 [ Html ] [ PDF Full-text ]
© 2021 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
