Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 10 / 16 / 2021

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Table of Contents

Editorial

Ariadne’s Thread in the Network of Hepatocellular Carcinoma Immunobiology
John Koskinas, Athanasios Armakolas
Abstract ] [ Html ] [ PDF Full-text ] 279-280 Doi: 10.14218/JCTH.2021.00140

Prediction and Prevention of Post-hepatectomy Liver Failure: Where Do We Stand?
Amr Shaaban Hanafy
Abstract ] [ Html ] [ PDF Full-text ] 281-282 Doi: 10.14218/JCTH.2021.00144

Original Article

PD-1 Involvement in Peripheral Blood CD8+ T Lymphocyte Dysfunction in Patients with Acute-on-chronic Liver Failure
Xiaoshuang Zhou, Yidong Li, Yaqiu Ji, Tian Liu, Ninghui Zhao, Jiefeng He, Jia Yao
Abstract ] [ Html ] [ PDF Full-text ] 283-290 Doi: 10.14218/JCTH.2020.00142

Development and Validation of a Nomogram Based on Perioperative Factors to Predict Post-hepatectomy Liver Failure
Bin Xu, Xiao-Long Li, Feng Ye, Xiao-Dong Zhu, Ying-Hao Shen, Cheng Huang, Jian Zhou, Jia Fan, Yong-Jun Chen, Hui-Chuan Sun
Abstract ] [ Html ] [ PDF Full-text ] 291-300 Doi: 10.14218/JCTH.2021.00013

Integrative Characterization of Immune-relevant Genes in Hepatocellular Carcinoma
Wei-Feng Hong, Yu-Jun Gu, Na Wang, Jie Xia, Heng-Yu Zhou, Ke Zhan, Ming-Xiang Cheng, Ying Cai
Abstract ] [ Html ] [ PDF Full-text ] 301-314 Doi: 10.14218/JCTH.2020.00132

Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging
Weixia Li, Ruokun Li, Xiangtian Zhao, Xiaozhu Lin, Yixing Yu, Jing Zhang, Kemin Chen, Weimin Chai, Fuhua Yan
Abstract ] [ Html ] [ PDF Full-text ] 315-323 Doi: 10.14218/JCTH.2020.00173

3-year Treatment of Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China
Jinlin Hou, Qin Ning, Zhongping Duan, You Chen, Qing Xie, Fu-Sheng Wang, Lunli Zhang, Shanming Wu, Hong Tang, Jun Li, Feng Lin, Yongfeng Yang, Guozhong Gong, John F. Flaherty, Anuj Gaggar, Shuyuan Mo, Cong Cheng, Gregory Camus, Chengwei Chen, Yan Huang, Jidong Jia, Mingxiang Zhang, GS-US-320-0110 and GS-US-320-0108 China Investigators
Abstract ] [ Html ] [ PDF Full-text ] 324-334 Doi: 14218/JCTH.2020.00145

Tenofovir Alafenamide Fumarate, Tenofovir Disoproxil Fumarate and Entecavir: Which is the Most Effective Drug for Chronic Hepatitis B? A Systematic Review and Meta-analysis
Xuefeng Ma, Shousheng Liu, Mengke Wang, Yifen Wang, Shuixian Du, Yongning Xin, Shiying Xuan
Abstract ] [ Html ] [ PDF Full-text ] 335-344 Doi: 10.14218/JCTH.2020.00164

Validation of the Nanjing Criteria for Diagnosing Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstruction Syndrome
Wei Zhang, Lu Liu, Ming Zhang, Feng Zhang, Chunyan Peng, Bin Zhang, Jun Chen, Lin Li, Jian He, Jiangqiang Xiao, Yanhong Feng, Xunjiang Wang, Aizhen Xiong, Li Yang, Xiaoping Zou, Yuecheng Yu, Yuzheng Zhuge
Abstract ] [ Html ] [ PDF Full-text ] 345-352 Doi: 10.14218/JCTH.2020.00124

Efficacy of Intragastric Balloons in the Markers of Metabolic Dysfunction-associated Fatty Liver Disease: Results from Meta-analyses
Zi-Yuan Zou, Jing Zeng, Tian-Yi Ren, Yi-Wen Shi, Rui-Xu Yang, Jian-Gao Fan
Abstract ] [ Html ] [ PDF Full-text ] 353-363 Doi: 10.14218/JCTH.2020.00183

Roles of SET7/9 and LSD1 in the Pathogenesis of Arsenic-induced Hepatocyte Apoptosis
Bing Han, Yi Yang, Lei Tang, Qin Yang, Rujia Xie
Abstract ] [ Html ] [ PDF Full-text ] 364-372 Doi: 10.14218/JCTH.2020.00185

Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK
Yue Wu, Ying Yang, Fang Li, Jie Zou, Yu-Hao Wang, Meng-Xia Xu, Yong-Lun Wang, Rui-Xi Li, Yu-Ting Sun, Shun Lu, Yuan-Yuan Zhang, Xiao-Dong Sun
Abstract ] [ Html ] [ PDF Full-text ] 373-383 Doi: 10.14218/JCTH.2021.00050

Predictive Value of Inflammation Biomarkers in Patients with Portal Vein Thrombosis
Jian-Bo Han, Qing-Hua Shu, Yu-Feng Zhang, Yong-Xiang Yi
Abstract ] [ Html ] [ PDF Full-text ] 384-391 Doi: 10.14218/JCTH.2020.00159

Characteristics and Inpatient Outcomes of Primary Biliary Cholangitis and Autoimmune Hepatitis Overlap Syndrome
Yi Jiang, Bing-Hong Xu, Brandon Rodgers, Nikolaos Pyrsopoulos
Abstract ] [ Html ] [ PDF Full-text ] 392-398 Doi: 10.14218/JCTH.2021.00008

Review Article

HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site
Dake Zhang, Ke Zhang, Urlike Protzer, Changqing Zeng
Abstract ] [ Html ] [ PDF Full-text ] 399-408 Doi: 10.14218/JCTH.2021.00062

A Review of Hepatitis B Virus and Hepatitis C Virus Immunopathogenesis
Corey Saraceni, John Birk
Abstract] [ Html ] [ PDF Full-text ] 409-418 Doi: 10.14218/JCTH.2020.00095

Direct-acting Antiviral Regimens for Patients with Chronic Infection of Hepatitis C Virus Genotype 3 in China
Xiaozhong Wang, Lai Wei
Abstract ] [ Html ] [ PDF Full-text ] 419-427 Doi: 10.14218/JCTH.2020.00097

Nonalcoholic Fatty Liver Disease after Liver Transplant
Akshay Shetty, Fanny Giron, Mukul K. Divatia, Muhammad I. Ahmad, Sudha Kodali, David Victor
Abstract ] [ Html ] [ PDF Full-text ] 428-435 Doi: 10.14218/JCTH.2020.00072

Current and New Drugs for COVID-19 Treatment and Its Effects on the Liver
Sandeep Satsangi, Nitin Gupta, Parul Kodan
Abstract ] [ Html ] [ PDF Full-text ] 436-446 Doi: 10.14218/JCTH.2020.00174

Case Report

Acute-on-chronic Liver Failure in a Patient with Candida Endophthalmitis: A Case Report
Ying Cao, Ying Fan, Yanbin Wang, Xiyao Liu, Wen Xie
Abstract ] [ Html ] [ PDF Full-text ] 447-451 Doi: 10.14218/JCTH.2020.00092

CASE REPORT

Acute-on-chronic Liver Failure in a Patient with Candida Endophthalmitis: A Case Report

Ying Cao1 , Ying Fan1 , Yanbin Wang1 , Xiyao Liu2 and Wen Xie1,*

1  Center of Liver Diseases, Capital Medical University Affiliated to Beijing Ditan Hospital, Beijing, China
2  Department of Ophthalmology, Capital Medical University Affiliated to Beijing Ditan Hospital, Beijing, China
*Correspondence to: Wen Xie, Center of Liver Diseases, Capital Medical University Affiliated to Beijing Ditan Hospital, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, China. ORCID:https://orcid.org/0000-0002-7314-8175. Tel: +86-10-84322816, Fax: +86-10-84322818, E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(3):447-451 DOI: 10.14218/JCTH.2020.00092
Received: October 11, 2020 Accepted: March 1, 2021 Published online: March 30, 2021

Abstract

Acute-on-chronic liver failure (ACLF) is a risk factor for fungal infection. Endogenous fungal endophthalmitis is a serious, sight-threatening disease. Common causes include immunocompromised state and intravenous drug use, permitting opportunistic pathogens to reach the eye through the blood stream. We report a case of Candida endophthalmitis in a 47 year-old woman who was admitted to our hospital with ACLF and poorly controlled diabetes. In addition, she was treated with glucocorticoids due to severe jaundice. After treatment for ACLF, the patient experienced fever with blurred vision in the left eye and was diagnosed with candidemia, endogenous Candida endophthalmitis in the left eye, and chorioretinitis in the right eye. Systemic and topical antifungal treatment was administered based on the positive Candida albicans test in intraocular fluid using second-generation sequencing. The patient underwent vitrectomy in the left eye and C. albicans was confirmed in vitreous cultures. Follow-up visit, at 6 weeks after the operation, showed only light perception in the left eye and stable visual acuity in the right eye. Physicians should be aware of endogenous fungal endophthalmitis in patients with ACLF, especially those with Candida infection, a history of glucocorticoid use, and diabetes. A dilated retinal examination should be performed by an ophthalmologist if ACLF patients develop fever and fungal infection.

Keywords

Acute-on-chronic liver failure, Candida endophthalmitis, Candida albicans, Glucocorticoid, Case report

Journal of Clinical and Translational Hepatology 2021 vol. 9, 447-451  [ Html  ] [ PDF Full-text ]

© 2021 Authors. This is an Open Access article distributed under the terms of the  Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

REVIEW ARTICLE

Current and New Drugs for COVID-19 Treatment and Its Effects on the Liver

Sandeep Satsangi1,*, Nitin Gupta2 and Parul Kodan3

1  Department of Apollo comprehensive Liver Care, Apollo Hospital, Bangalore, Karnataka, India
2  Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
3  Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
*Correspondence to: Sandeep Satsangi, Consultant Hepatologist & Liver Transplant Physician, Department of Apollo comprehensive Liver Care, Apollo Hospital, Bangalore, Karnataka 560076, India. Tel: +91-7899243962, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2021;9(3):436-446 DOI: 10.14218/JCTH.2020.00174
Received: December 21, 2020 Accepted: March 18, 2021 Published online: April 19, 2021

Abstract

Corona virus disease (COVID)-19 is caused by the novel severe acute respiratory syndrome coronavirus-2 (commonly referred to as SARS-CoV-2). In March 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Though the target organ for the virus is primarily the lungs, with the recent understanding of the pathobiology of this disease and the immune dysregulation associated with it, it is now clear that COVID-19 affects multiple organ systems. Several drugs and therapies have been tried or repurposed to combat the wrath posed by this disease. On October 22, 2020, the USA Food and Drug Administration approved remdesivir for use in adults and pediatric patients (12 years of age and older). Several of the drugs being tried against COVID-19 have hepatotoxicity as their potential side effect. This review aims to provide the latest insights on various drugs being used in the treatment of COVID-19 and their effects on the liver.

Keywords

COVID-19, Drugs, Liver, Drug-induced liver injury

Journal of Clinical and Translational Hepatology 2021 vol. 9, 436-446  [ Html  ] [ PDF Full-text ]

© 2021 Authors. This is an Open Access article distributed under the terms of the  Creative Commons Attribution-Noncommercial 4.0 License(CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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